极低出生体重儿支气管肺发育不良的高危因素分析

目的:探讨极低出生体重儿发生支气管肺发育不良(Bronchopulmonary Dysplasia,BPD)的临床高危因素。方法:回顾性分析NICU收治的极低出生体重儿199例患儿的临床资料,根据是否发生BPD分为BPD组和非BPD组,分析BPD发生的可能危险因素。结果:199例低出生体重儿中有48例发生BPD,发病率为24.1%。与非BPD患儿组相比,BPD组患儿在机械通气时间、总吸氧时间、吸氧浓度>40%时间、宫内感染、合并动脉导管未闭、院内感染等方面比较差异有统计学意义(P<0.05),Logistic回归分析结果显示机械通气时间、宫内感染、吸氧浓度>40%时间为疾病发生的危险因素。结论:预防宫内感染可降低BPD的发生率,长时间机械通气及高浓度吸氧为BPD发生的高危因素。

Analysis on high risk factors of bronchopulmonary dysplasia in very low birth weight infants

Objective:To explore the clinical high risk factors of bronchopulmonary dysplasia(BPD) in very low birth weight infants.Methods:The clinical data of 199 very low birth weight infants who were treated in NICU of the hospital were analyzed retrospectively,then they were divided into BPD group and non-BPD group;the probable risk factors of BPD were analyzed.Results:Among 199 very low birth weight infants,48 infants were diagnosed as BPD,the morbidity was 24.1%.There were statistically significant differences in the time of mechanical ventilation,the time of oxygen inhalation,the time of oxygen inhalation with oxygen concentration>40%,intrauterine infection,combined with patent ductus arteriosus,and nosocomial infection between BPD group and non-BPD group(P<0.05);the results of logistic regression analysis showed that the time of mechanical ventilation,intrauterine infection,and the time of oxygen inhalation with oxygen concentration>40% were the risk factors of BPD.Conclusion:Preventing intrauterine infection can reduce the morbidity of BPD,mechanical ventilation for a long time and oxygen inhalation with high oxygen concentration are high risk factors of BPD.