| Nrf2/ARE信号通路及其相关药物研究进展 |
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| 引用本文： | 潘晓菲,谭初兵,时丽丽,张洁,徐为人,汤立达.Nrf2/ARE信号通路及其相关药物研究进展[J].药物评价研究,2013(1):54-58. |
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| 作者姓名： | 潘晓菲 谭初兵 时丽丽 张洁 徐为人 汤立达 |
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| 作者单位： | 天津药物研究院;天津医科大学药学院 |
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| 基金项目： | 国家重大新药创制专项(2011ZX09401-009) |
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| 摘 要： | Nrf2/ARE信号通路是细胞氧化应激反应中的关键通路,其调控的下游抗氧化蛋白和Ⅱ相解毒酶在细胞防御保护中发挥重要作用。现有研究显示Nrf2/ARE通路在抗炎、抗肿瘤、神经保护、抗凋亡等多方面具有重要作用,以Nrf2为靶点的药物有望用于多发性硬化、糖尿病、神经退行性疾病、肿瘤等多种疾病的治疗,其中已有富马酸二甲酯、巴多克沙龙等多个新药进入临床研究阶段。就Nrf2/ARE通路与疾病的关系及以其为靶点的新药研发进展做一综述。
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| 关 键 词： | Nrf2 ARE通路 抗氧化 转录因子 巴多克沙龙 富马酸二甲酯 |
Advances in study on Nrf2/ARE signal pathway and its relevant drugs |
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| PAN Xiao-fei,TAN Chu-bing,SHI Li-li,ZHANG Jie,XU Wei-ren,TANG Li-da.Advances in study on Nrf2/ARE signal pathway and its relevant drugs[J].Drug Evaluation Research,2013(1):54-58. |
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| Authors: | PAN Xiao-fei TAN Chu-bing SHI Li-li ZHANG Jie XU Wei-ren TANG Li-da |
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| Institution: | 1.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 2.School of Pharmacy,Tianjin Medical University,Tianjin 300070,China |
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| Abstract: | Nrf2/antioxidant-response-element（ARE） signal pathway is vital in the regulation of cellular oxidative stress response,and the downstream anti-oxidant proteins and phase Ⅱ detoxification enzyme,which were regulated by Nrf2/ARE pathway,play the important roles in the cellular defense protection.Nrf2/ARE pathway plays a key role in the anti-inflammatory,antitumor,neuroprotective,and anti-apoptotic effects.Drugs targeted on Nrf2 are expected to be used in the treatment of several diseases such as multiple sclerosis,diabetes,neurodegenerative diseases,and tumors;Some new drugs such as dimethyl fumarate and Bardoxolone have advanced into late clinical phase.This paper introduces the relationship between Nrf2/ARE pathway and diseases as well as the development of drugs targeted on it. |
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