昂丹司琼单用与联用地塞米松预防腹部术后恶心呕吐效果的Meta分析

目的评价昂丹司琼单用与联用地塞米松预防腹部术后恶心、呕吐的效果。方法通过检索PubMed、中国知网和万方数据库,搜集以昂丹司琼单用与联用地塞米松预防腹部术后恶心呕吐的随机对照试验研究（ran-dom controlled trial,RCT）。以昂丹司琼单用组为对照组,以昂丹司琼单用与联用地塞米松组为试验组,采用Meta分析评价昂丹司琼联用地塞米松预防术后恶心、呕吐的效果。结果共纳入11篇文献,共1 021例腹部手术患者,其中试验组509例,对照组512例。Meta分析结果显示,试验组预防腹部术后恶心、呕吐效果均优于对照组（P〈0.05）。预防恶心和呕吐合并效应比值比（odd ratio,OR）及95%可信区间（confidence interval,CI）分别为2.73（1.71,4.34）和3.20（1.86,4.92）。结论昂丹司琼联用地塞米松能够有效预防腹部术后恶心、呕吐的发生,但是仍需要严格、标准、高质量、大样本、长期随访证实昂丹司琼联用地塞米松的安全性和有效性。

Meta-analysis of Ondansetron and Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery

Objective To evaluate the efficacy of Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery.Methods PubMed,CNKI and Wanfang electronic databases were searched to collected randomized controlled trials（RCT） that were interfere in Ondansetron or Ondansetron combined with Dexamethasone in controlling postoperative nausea and vomiting,Ondansetron was taken as control group,Ondansetron combined with Dexamethasone was taken as test group,The efficacy of Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery with Meta-analysis was evaluated.Results 11 RCT and 1 021 patients with abdominal surgery were included.There was 509 cases in test groups and 512 cases in control group,Meta analysis showed that the test group was better than the control group in improving the incidence of the total postoperative nausea and vomiting（P〈0.05）,the overall efficacy of OR and 95%CI of the total postoperative nausea and vomiting was 2.73（1.71,4.34） and 3.20（1.86,4.92）.Conclusion Ondansetron combined with Dexamethasone can improve postoperative nausea and vomiting after abdominal surgery.However,more scientific and standardized,high quality,large sample,long-term follow-up of the study is still needed for evaluating safety and efficacy of Ondansetron combined with Dexamethasone for preventing postoperative nausea and vomiting after abdominal surgery