| 高效液相色谱法对坎地沙坦酯固体分散体颗粒溶出度的测定 |
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| 引用本文： | 朱燕妮,傅璐仙,徐飞瑶,张戈辉,范长春.高效液相色谱法对坎地沙坦酯固体分散体颗粒溶出度的测定[J].中国医药导报,2013,10(3):127-129. |
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| 作者姓名： | 朱燕妮 傅璐仙 徐飞瑶 张戈辉 范长春 |
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| 作者单位： | 台州职业技术学院生化制药研发中心 |
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| 基金项目： | 浙江省大学生科技创新活动计划(新苗人才计划)项目(项目编号:2011R460002) |
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| 摘 要： | 目的建立用于测定坎地沙坦酯固体分散体颗粒溶出度的高效液相测定方法。方法采用《中国药典》2010年版二部溶出度测定法二法,以乙腈-水-冰醋酸（57∶43∶1）为流动相,流速为1 mL/min,检测波长为254 nm,测定溶出液的浓度。结果所得溶液线性范围为0.42～67.20 mg/L（A=29.436 3C＋31.424 4,r=0.999 8）,平均回收率99.7%（RSD=0.3%）。结论本方法准确可靠,可用于坎地沙坦酯速释、缓释颗粒及片剂的溶出度测定。
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| 关 键 词： | 坎地沙坦酯 高效液相色谱法 溶出度 固体分散体 颗粒 |
Determination of dissolution for Solid Dispersion Granules of Candesartan Cilexetil with HPLC method |
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| ZHU Yanni,FU Luxian,XU Feiyao,ZHANG Gehui,FAN Changchun.Determination of dissolution for Solid Dispersion Granules of Candesartan Cilexetil with HPLC method[J].China Medical Herald,2013,10(3):127-129. |
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| Authors: | ZHU Yanni FU Luxian XU Feiyao ZHANG Gehui FAN Changchun |
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| Institution: | Pharmaceutical R&D Center,Taizhou Vocational and Technical College,Zhejiang Province,Taizhou 318000,China |
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| Abstract: | Objective To establish HPLC method for the determination of Solid Dispersion Granules of Candesartan Cilexetil.Methods Method Ⅱ of determination of dissolution in Chinese Pharmacopeia（2010 edition,Part Ⅱ）,and HPLC was employed to detect the concentration with conditions that acetonitrile-water-acetic acid（57：43：1） as mobile phase with flow rate of 1 mL/min,and detection wavelength of 254 nm.Results The linear range was 0.42-67.20 mg/L（A = 29.436 3C＋31.424 4,r = 0.999 8）,the average recovery rate was 99.7%（RSD = 0.3%）.Conclusion The method is accurate and reliable,and can be used for determination of dissolution for Immediate-Release Granules,Sustained Release Granules and Tablets of Candesartan Cilexetil. |
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| Keywords: | Candesartan Cilexetil HPLC Dissolution Solid dispersion Granules |
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