CT、UU感染与不孕不育临床研究及UU耐药性分析

目的:分析泌尿生殖系沙眼衣原体(CT)和解脲支原体(UU)感染与不孕不育之间的关系以及UU感染的耐药性。方法:以246例不孕不育妇女为观察组,134例正常生育妇女为对照组,观察两组的CT、UU感染阳性率差异,分析观察组中CT、UU感染阳性及阴性患者的上生殖道炎症、输卵管堵塞情况以及UU感染的耐药性。结果:两组CT、UU及CT、UU混合感染率经卡方检验,差异有统计学意义(P<0.001)。观察组中CT、UU感染阳性及阴性患者的上生殖道炎症及输卵管堵塞情况经卡方检验,差异有统计学意义(P<0.001);UU感染药敏分析以多西环素、米诺环素比较敏感,环丙沙星、诺氟沙星耐药现象比较严重。结论:泌尿生殖系CT、UU感染与不孕不育关系密切;药敏试验能很好地指导临床药物使用,能有效减少耐药菌株的产生。

Clinical research on relationship between Chlamydia trachomatis,Ureaplasma urealyticum infection and infertility and drug resistance analysis of Ureaplasma urealyticum

Objective:To analyze the relationship between Chlamydia trachomatis(CT),Ureaplasma urealyticum(UU) infection and infertility and drug resistance of UU.Methods:A total of 246 infertile women were selected as observation group,and 134 women with normal infertility were selected as control group;the positive rates of CT and UU in the two groups were observed,the prevalences of upper reproductive tract inflammation and tubal obstruction in patients with positive and negative CT infection and UU infection and drug resistance of UU infection in the two groups were analyzed and observed.Results:There were statistically significant differences in infection rates of CT and UU,and mixed infection rate of CT and UU between the two groups(P<0.001);in observation group,there were statistically significant differences in the prevalences of upper reproductive tract inflammation and tubal obstruction between patients with positive CT infection and UU infection and patients with negative CT infection and UU infection(P<0.001);the results of drug sensitive test showed that UU was sensitive to doxycycline and minocyline,drug resistances of ciprofloxacin and norfloxacin were serious.Conclusion:CT and UU infection of urogenital system are closely related to infertility;drug sensitive test can direct clinical drug use and reduce drug resistant strains effectively.