心肌酶谱在类风湿性关节炎患者血清中的变化及临床意义

目的探讨心肌酶谱检测对类风湿性关节炎（RA）患者临床价值。方法回顾分析42例活动性RA患者（活动组）、37例非活动性RA患者（非活动组）、40例健康体检者（对照组）的血清天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶MB同工酶（CK-MB）等指标的检测结果,其中AST、LDH、CK测定采用速率法,CK-MB测定采用免疫抑制法。结果①三组患者的血清AST、LDH、CK、CK-MB比较差异有统计学意义（P〈0.05）;活动组的血清AST、LDH、CK、CK-MB显著高于非活动组（P〈0.05）,非活动组的血清AST、LDH、CK、CK-MB显著高于对照组（P〈0.05）。②治疗后,活动组患者血清AST、LDH、CK、CK-MB均显著下降,治疗前后相比差异有统计学意义（P〈0.05）。结论 RA患者常伴随有心肌细胞损伤。在RA患者诊治过程中,应定期监测其心肌酶谱,以防心脏不良事件的发生。

Variation and clinical significance of serum cardiac enzymes in patients with rheumatoid arthritis

Objective To explore the clinical value of detection of cardiac enzymes in patients with rheumatoid arthritis（RA）.Methods The results of serum aspartate aminotransferase（AST）,lactate dehydrogenase（LDH）,creatine kinase（CK）,creatine kinase MB isoenzyme（CK-MB） in 42 cases of active RA（active group）,37 cases of inactive RA（inactive group） and 40 cases of healthy subjects（control group） were analyzed retrospectively,and the AST,LDH and CK were detected by rate method,while the CK-MB was detected by immunosuppression method.Results ①There were significant differences in AST,LDH,CK and CK-MB among the three groups（P 0.05）.The AST,LDH,CK and CK-MB in active group were significantly higher than those in inactive group respectively（P 0.05）,which were significantly higher than those in control group respectively（P 0.05）.②Compared with before treatment,the AST,LDH,CK and CK-MB in active group decreased significantly after treatment（P 0.05）.Conclusion It is often to find myocardial cell injury in patients with PA.To prevent the occurrence of myocardial damage,should monitor the cardiac enzymes periodically during the diagnosis and treatment of patients with RA.