东莞地区流动人口女性HPV感染危险因素调查及治疗效果

目的:了解东莞地区流动女性人乳头瘤病毒(HPV)的感染情况及其危险因素并探讨中药治疗宫颈HPV感染的疗效。方法:对3142名流动育龄女性进行保密式问卷调查并采用HCⅡ法进行HPV分型检测,同时进行液基细胞学检查(TCT);将304名高危HPV感染阳性患者分为中药组95例、α干扰素治疗组95例、对照组94例,治疗1～3个疗程复查HPV转阴情况。结果:高危型HPV感染率为9.7%。初中及以下文化程度、结婚年龄≤20岁、分娩年龄≤20岁、性生活频率每周3次及以上的女性HPV感染率明显升高;患者治疗1～3个疗程后中药组和α干扰素组转阴率明显高于对照组,且治疗3个疗程后中药组转阴率明显高于α干扰素组。结论:文化程度低、早婚早育、性生活过频是宫颈HPV感染的危险因素,中药可有效治疗宫颈HPV感染,预防宫颈癌的发生。

Investigation on risk factors of HPV infection in floating women in Dongguan city and curative effect

Objective:To understand the infectious status and risk factors of human papillomavirus(HPV) in floating women in Dongguan city,and explore the curative effect of traditional Chinese medicine for treatment of cervical HPV infection.Methods:A total of 3 142 floating women of childbearing age were surveyed by a confidential questionnaire,and HC Ⅱ method was used for HPV classification and detection,liquid-based thin-layer cytologic test was performed during the same period;304 patients with high risk HPV infection were divided into traditional Chinese medicine group(95 patients),α-interferon treatment group(95 patients),and control group(94 patients),the negative conversion rates of HPV were reexamined after 1-3 courses of treatment in the three groups.Results:The infection rate of high-risk HPV was 9.7%.The infection rates were significant higher among the women who had educational level of junior high school or below,marriage age≤20 years,delivery age≤20 years,the frequency of sexual life 3 times per week or more.After 1-3 courses of treatment,the negative conversion rates in traditional Chinese medicine group and α-interferon treatment group were significantly higher than those in control group,and after 3 courses of treatment,the negative conversion rate in traditional Chinese medicine group was significantly higher than that in α-interferon treatment group.Conclusion:Low educational level,early marriage or early childbearing,and too frequent sexual life were risk factors of cervical HPV infection.Traditional Chinese medicine can treat cervical HPV infection effectively and prevent cervical cancer.