Survivin基因-31C/G多态性与子痫前期的相关性研究

目的:探讨Survivin基因-31C/G多态性和子痫前期的发病及其严重程度的相关性。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术以96例患有子痫前期的孕妇(其中轻度子痫前期52例,重度子痫前期44例)和110例在郑州大学第二附属医院、郑州市妇幼保健院进行产前检查并分娩的正常孕妇为研究对象,检测Survivin基因-31C/G多态性分布的基因型。结果:G等位基因型频率在子痫前期组高于对照组(P<0.05),G等位基因型频率在重度子痫前期组高于轻度子痫前期组(P<0.05)。结论:Survivin基因-31C/G多态性的G等位基因可能是中原地区汉族妇女发生子痫前期的遗传危险因素,并与病情严重程度有关。

Study on correlation between Survivin gene-31C/G polymorphism and preeclampsia

Objective:To explore the correlation between Survivin gene-31C/G polymorphism and onset of preeclampsia and its degree of severity.Methods:Ninety-six pregnant women with preeclampsia(including 52 pregnant women with mild preeclampsia and 44 pregnant women with severe preeclampsia) and 110 normal pregnant women who received prenatal examination and gave birth to their babies in the hospital and Zhengzhou maternal and child health hospital were selected as research objects,then PCR-RFLP was used to detect genotypes of Survivin gene-31C/G polymorphism.Results:The frequency of G allele in preeclampsia group was statistically significantly higher than that in control group(P<0.05);and the frequency of G allele in severe preeclampsia group was statistically significantly higher than that in mild preeclampsia group(P<0.05).Conclusion:G allele of Survivin gene-31 C/G polymorphism may be one of genetic risk factors of preeclampsia for Chinese women in central China and it may also be associated with its degree of severity.