多巴胺联合多巴酚丁胺治疗新生儿窒息后肾损害的临床观察

目的:观察多巴胺和多巴酚丁胺联合治疗新生儿窒息后肾损害的临床应用价值。方法:收集2011年1月～2012年7月期间新乡市妇幼保健院新生儿重症监护病房的新生儿窒息患儿240例,其中肾损害130例,将患儿随机分为对照组(n=60)和多巴胺联合多巴酚丁胺治疗组(n=70)。检测患儿治疗前后血尿素氮和肌酐的表达变化,统计分析两组治疗效果。结果:该院新生儿窒息肾损害的发生率为54.5%。对照组和治疗组在治疗前血尿素氮和肌酐的表达水平无统计学差异(P>0.05),治疗后治疗组对血尿素氮和肌酐的减低效果显著优于对照组(P<0.05)。治疗组的临床治疗有效率为94.3%显著高于对照组的73.3%(P<0.05)。结论:多巴胺联合多巴酚丁胺辅助治疗新生儿窒息后肾损害临床疗效显著,值得临床推广应用。

Clinical observation on dopamine combined with dobutamine for treatment of renal injury after neonatal asphyxia

Objective:To observe the clinical application values of dopamine combined with dobutamine for treatment of renal injury after neonatal asphyxia.Methods:A total of 240 neonates with asphyxia from neonatal ICU in the hospital from January 2011 to July 2012 were collected,including 130 neonates with renal injury,then they were divided into control group(60 neonates) and combined treatment group(70 neonates treated with dopamine combined with dobutamine).The changes of blood urea nitrogen and creatinine before and after treatment were detected,the curative effects in the two groups were analyzed statistically.Results:The incidence rate of renal injury in neonates with asphyxia was 54.5%.There was no statistically significant difference in the expression levels of blood urea nitrogen and creatinine before and after treatment between control group and combined treatment group(P>0.05).After treatment,the decreasing amplitudes of blood urea nitrogen and creatinine in combined treatment group were better than those in control group(P<0.05).The clinical effective rate in combined treatment group was 94.3%,which was statistically significantly higher than that in control group(73.3%)Conclusion:The clinical efficacy of dopamine combined with dobutamine for treatment of renal injury after neonatal asphyxia is dominant,which is worthy to be popularized in clinic.