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PLLA/HA复合材料电纺丝覆膜气管支架的制作及力学性能的基础研究
引用本文:马永富,刘阳,梁朝阳,郭俊唐,张涛.PLLA/HA复合材料电纺丝覆膜气管支架的制作及力学性能的基础研究[J].中国医药导报,2013,10(3):154-157.
作者姓名:马永富  刘阳  梁朝阳  郭俊唐  张涛
作者单位:解放军总医院胸外科
基金项目:解放军总医院苗圃基金(编号06MP21)
摘    要:目的自行研制羟基磷灰石/聚左旋乳酸(PLLA/HA)复合材料支架,测试机械力学性能;制备PLLA/HA复合纳米纤维膜,观察纤维膜的结构形态。方法将一定比例HA复合于PLLA中,制膜切丝,自制支架,测试支架力学性能;电纺丝法行支架电纺丝覆膜,扫描电镜观察其形态。结果 PLLA/HA复合材料电纺丝覆膜支架的力学性能良好,结构形态符合组织工程材料要求。结论 PLLA/HA复合材料电纺丝覆膜支架可以满足气管内支架置入要求,是气管内支架的一种新型材料。

关 键 词:气管  支架  电纺丝  聚左旋乳酸  机械性能

Mechanical properties of PLLA/HA biodegradable stent by electrospinning in the use of trachea stent
MA Yongfu,LIU Yang,LIANG Chaoyang,GUO Juntang,ZHANG Tao.Mechanical properties of PLLA/HA biodegradable stent by electrospinning in the use of trachea stent[J].China Medical Herald,2013,10(3):154-157.
Authors:MA Yongfu  LIU Yang  LIANG Chaoyang  GUO Juntang  ZHANG Tao
Institution:Department of Thoracic Surgery,Chinese PLA General Hospital,Beijing 100853,China
Abstract:Objective To design a kind of electrospinning trachea stent with PLLA and HA composite,and its me chanical properties were studied.The structure of fiber membrane was observed.Methods PLLA/HA composite nanofiber was prepared by electrospinning method.The structure of fiber membrane was observed by scanning electron microscopy,and the mechanical properties were studied.Results The surface of hybrid fibers was much coarser because of the introduction of HA nano-particles,and the mechanical properties were well.Conclusion The properties of the biodegradable trachea stent with PLLA and HA composite is available for further study.
Keywords:Trachea  Stent  Electrospinning  Poly-L-lactic acid  Mechanical properties
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