交泰丸联合盐酸多奈哌齐治疗血管性痴呆45例临床研究

目的观察交泰丸联合盐酸多奈哌齐治疗血管性痴呆（vasculardementia，VD）的临床疗效。方法90例VD患者按随机数字表法随机分为两组，治疗组45例采用交泰丸0．02g／（kg·d），2次／d，早晚饭后口服，同时予盐酸多奈哌齐5mg每晚临睡前口服，共治疗4周。对照组45例采用盐酸多奈哌齐5mg每晚临睡前口服，共治疗4周。观察治疗4周后的临床疗效，以及治疗4周后评价简易精神状况检查量表（MMSE）、日常生活能力（ADL）的变化。结果治疗组治疗后的显效率和总有效率均明显高于对照组（P〈0．05）；并且治疗组治疗后MMSE和ADL评分均明显高于对照组（P〈0．05）。结论交泰丸联合盐酸多奈哌齐治疗VD疗效显著，优于单独使用盐酸多奈哌齐。

Clinical research on Jiaotai Pill combined with Donepezil Hydrochloride in the treatment of 45 patients with vascular dementia

Objective To observe the clinical efficacy on Jiaotai Pill combined with Donepezil Hydrochloride in the treatment of vascular dementia （VD）. Methods 90 patients with VD were randomly divided into treatment group and control group. 45 patients in the treatment group were given Jiaotai Pill 0.02 g/（kg. d）, 2 time a day after breakfast and supper, meanwhile they were given 5 mg Donepezil Hydrochloride orally at bedtime every night. 45 patients in the control group were given 5 mg Donepezil Hydrochloride orally at bedtime every night. Patients of two groups were treated for 4 weeks. The clinical efficacy after 4 weeks treatment and the changes of MMSE and ADL before and after 4 weeks treatment were observed. Results After treatment, the treatment group was better than the control group obvi- ously in the aspect of apparent rate and the total effective rate （P 〈 0.05）. The MMSE and ADL scores of treatment group were better than that of control group obviously （P 〈 0.05）. Conclusion The Jiaotai Pill combined with Donepezil Hydroehloride in the treatment of vascular dementia （VD） is very effective in clinical efficacy. The clinical efficacy is better than using Donepezil Hydrochloride alone.