育龄妇女生殖道感染综合干预效果的Meta分析

目的:综合评价生殖道感染的综合干预对控制我国育龄妇女内源性生殖道感染的效果。方法:检索近10年国内发表的关于育龄妇女细菌性阴道病和念珠菌性阴道炎的干预效果的研究。筛选文献、提取数据资料和进行质量评价后,采用RevMan5.0软件进行Meta分析。结果:共纳入13个研究,包括5个群组随机对照研究和8个干预前后对照研究,结果显示:①群组随机对照研究:细菌性阴道病患病率合并OR值为0.56(95%CI:0.37,0.84),念珠菌性阴道炎患病率合并OR值为0.50(95%CI:0.40,0.64);干预组患病率比对照组低。②干预前后对照研究:干预后细菌性阴道病患病率比干预前低(RD=-0.04,95%CI:-0.05,-0.02),干预后念珠菌性阴道炎患病率比干预前低(RD=-0.06,95%CI:-0.08,-0.03)。结论:在育龄妇女中进行生殖道感染的综合干预对降低生殖道感染的患病率有一定积极的作用。

Effect of comprehensive intervention for reproductive tract infection among women of childbearing age: a meta analysis

Objective:To evaluate the effect of comprehensive intervention on reproductive tract infection among women of childbearing age in China.Methods:A comprehensive literature search was carried out to collect all related studies in China from 2001 to 2011,in which the effects of intervention on bacterial vaginal disease and monilial vaginitis were evaluated.After selecting,extracting,and evaluating all the studies,meta-analysis was carried out by RevMan5.0 software.Results:A total of 13 studies were selected for meta analysis based on inclusion and exclusion criteria,which included 5 cluster randomized studies and 8 before-after studies.Cluster randomized studies: the pooled odds ratios and 95%CIs for the prevalences of bacterial vaginal disease and monilial vaginitis were 0.56(95%CI: 0.37,0.84) and 0.50(95%CI: 0.40,0.64),respectively.The prevalence in intervention group was lower than that in control group.Before-after studies: the comprehensive intervention was effective in reducing the prevalences of bacterial vaginal disease(RD=-0.04,95%CI:-0.05,-0.02) and monilial vaginitis(RD=-0.06,95%CI:-0.08,-0.03).Conclusion:The comprehensive intervention on reproductive tract infection among women of childbearing age was effective in reducing the prevalences of bacterial vaginal disease and monilial vaginitis.