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| 神经生长因子对噪声暴露下毛细胞的保护作用 | |
| 引用本文： | 池君,宋武战,范泉水,冯子良,薛希均. 神经生长因子对噪声暴露下毛细胞的保护作用[J]. 西南国防医药, 2011, 21(11): 1161-1163. DOI: 10.3969/j.issn.1004-0188.2011.11.001 |
| 作者姓名： | 池君 宋武战 范泉水 冯子良 薛希均 |
| 作者单位： | 1. 成都军区昆明总医院耳鼻喉科,昆明,650032 2. 成都军区昆明总医院核医学科,昆明,650032 3. 成都军区疾病预防控制中心博士后科研工作站 |
| 基金项目： | 国家博士后基金一等资助项目 |
| 摘 要： | 目的观察神经生长因子（nervegrowthfactor，NGF）对噪声暴露下豚鼠耳蜗毛细胞的保护作用。方法健康杂色成年豚鼠20只，随机分成两组，每组10只。A组：强噪声暴露（非手术）组，B组：注射重组腺病毒（携带NGF基因并能表达NGF蛋白质）后，强噪声暴露。噪声暴露7d后，各组均行耳蜗石蜡切片、HE染色和耳蜗基底膜铺片，计数毛细胞。结果A组豚鼠耳蜗基底膜细胞不连续，毛细胞变形，部分毛细胞缺失，螺旋神经节发出的神经纤维与毛细胞的连接断裂；B组耳蜗结构没有明显变化，B组毛细胞数日明显高于A组（P〈0．01）。结论NGF对噪声暴露下的耳蜗毛细胞具有一定的保护作用。 |
| 关 键 词： | 神经生长因子 噪声 毛细胞 |
Protection effects of nerve growth factor on hair cells exposed to noise |
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| Chi Jun,Song Wuzhan,Fan Quanshui,Feng Ziliang,Xue Xijun. Protection effects of nerve growth factor on hair cells exposed to noise[J]. Medical Journal of National Defending forces in Southwest China, 2011, 21(11): 1161-1163. DOI: 10.3969/j.issn.1004-0188.2011.11.001 | |
| Authors: | Chi Jun Song Wuzhan Fan Quanshui Feng Ziliang Xue Xijun |
| Affiliation: | Chi Jun1,Song Wuzhan2,Fan Quanshui3,Feng Ziliang3,Xue Xijun1 1.Department of Otolaryngology,2.Department of Nuclear Medicine,Kunming General Hospital of Chengdu Military Command,Kunming,Yunnan,650032,China,3.Post-doctoral Scientific Research Workstation,Center for Control and Prevention of Diseases of Chengdu Military Command,Chengdu,Sichuan,610021 |
| Abstract: | Objective To observe the protection effects of nerve growth factor(NGF)on the guinea pig's cochleae hair cells exposed to noise.Methods Twenty healthy variegated adult guinea pigs were randomly divided into two groups,and each group contained 10 animals.Group A was exposed to strong noise(non-injection).Group B was exposed to the strong noise after the injection of recombinant adenovirus which carried NGF gene and could express the NGF protein.Seven days after the noise exposure,the cochleae in both two gro... |
| Keywords: | nerve growth factor noise hair cell |
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