| 顶空气相色谱法测定羟乙基淀粉中有机溶剂残留量 |
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| 引用本文： | 宋更申,周丽,孙玉静.顶空气相色谱法测定羟乙基淀粉中有机溶剂残留量[J].中国药业,2010,19(8):31-32. |
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| 作者姓名： | 宋更申 周丽 孙玉静 |
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| 作者单位： | 1. 河北省药品检验所,河北石家庄,050011
2. 沈阳华泰药物研究所,辽宁沈阳,110300 |
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| 摘 要： | 目的 建立测定羟乙基淀粉中2种有机溶剂残留量的顶空气相色谱法。方法检测器为FID检测器，色谱柱为DB-FFAP毛细管柱（30m×0．53mm,1．5μm），进样口温度为180℃，柱温为90℃，检测器温度为250℃。结果甲醇和环氧乙烷质量浓度线性范围分别为0．12～3．00mg／mL和0．0004～0．01mg／mL，可同时测定2组分。结论该方法操作简单，结果准确、可靠。
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| 关 键 词： | 羟乙基淀粉 有机溶剂残留量 顶空气相色谱法 |
Determination of Methanol and Ethylene Oxide in Hydroxyethyl Starch by Headspace Gas Chromatography |
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| Song Gengshen,Zhou Li,Sun Yujing.Determination of Methanol and Ethylene Oxide in Hydroxyethyl Starch by Headspace Gas Chromatography[J].China Pharmaceuticals,2010,19(8):31-32. |
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| Authors: | Song Gengshen Zhou Li Sun Yujing |
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| Institution: | 1. Hebei Institute for Drug Control, Shijiazhuang, Hebei, China 050011; 2. Shenyang Pharmtech Institute of Pharmaceuticals, Shenyang , Liaoning, China 110300) |
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| Abstract: | Objective To establish a headspace GC method for the determination of the residual organic solvents in hydroxyethyl starch. Methods The residual organic solvents were quantitatively determined by headspaee GC with the FID detector, he capillary column was DB-FFAP. The injector temperature was 180 ℃ ,the column temperature was 90 ℃ ,and the detector temperature was 250 ℃. Results Methaol and ethylene oxide linear in the range of concentrations 0. 12-3.00 mg/mL and 0.000 4-0.01 mg/mL, simultaneous determination. Conclusion The proposed method is easily operative,simple,accurate and rapid with good sensitivity. |
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| Keywords: | hydroxyethyl starch residual organic solvents headspace GC |
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