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Effects of arginase inhibitors on the contractile and relaxant responses of isolated human penile erectile tissue |
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| Authors: | Johan M. Lorenzen Stefan Ückert Friedemann Scheller Hermann Haller Markus A. Kuczyk |
| Affiliation: | (1) Department of Urology and Uro-Oncology, Hannover Medical School, 30625 Hannover, Germany;(2) Department of Nephrology, Hannover Medical School, 30625 Hannover, Germany;(3) Department of Nuclear Medicine, Hannover Medical School, 30625 Hannover, Germany;(4) Division of Nephrology, Department of Internal Medicine, Hannover Medical School, 30623 Hannover, Germany |
| Abstract: | ObjectivesAn impairment in the local availability of nitric oxide (NO) may impair male erectile function. The activity of l-arginine-degrading arginase enzymes may attenuate the relaxation of cavernous smooth muscle by reducing local NO production. Arginase enzymes compete with the nitric oxide synthases for the common substrate, the amino acid l-arginine. Very little data are available regarding the significance of arginase enzymes in the control of human penile erectile tissue. The aim of the present study was to elucidate the effects of drugs known to inhibit arginase activity on the relaxation of isolated human corpus cavernosum (HCC) and the production of cyclic GMP. |
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