| 血红素加氧酶-Ⅰ与实体肿瘤 |
| |
| 引用本文： | 王波,于景翠,周虹.血红素加氧酶-Ⅰ与实体肿瘤[J].医学分子生物学杂志,2008,5(4). |
| |
| 作者姓名： | 王波 于景翠 周虹 |
| |
| 作者单位： | 1. 军事医学科学院野战输血研究所,北京市,100850
2. 哈尔滨医科大学第二临床医院,哈尔滨市,150081 |
| |
| 摘 要： | 血红素加氧酶-1(heme oxygenase-1,HO-1)是血红素分解代谢的关键酶,它能催化血红素降解释放出胆绿素、CO和Fe2 。它参与维持细胞稳态,并在降低氧化损伤、减轻炎性反应、抑制细胞凋亡和调节细胞增殖等方面发挥重要作用。近年研究发现,HO-1与肿瘤相关,尤其与实体瘤关系较为密切。HO-1既可通过抗凋亡作用促进某些肿瘤快速增长,又可对某些肿瘤细胞发挥有效的抗增殖作用。文章综述了HO-1表达变化、HO-1基因多态性、HO-1抗凋亡等特征与实体瘤发生、发展的关系。
|
| 关 键 词： | 血红素加氧酶-1 实体肿瘤 |
HO-1 and Solid Tumor |
| |
| WANG Bo,YU Jingcui,ZHOU Hong.HO-1 and Solid Tumor[J].Journal of Medical Molecular Biology,2008,5(4). |
| |
| Authors: | WANG Bo YU Jingcui ZHOU Hong |
| |
| Institution: | WANG Bo1,YU Jingcui2,ZHOU Hong11Institute of Transfusion Medicine,Academy of Military Medical Sciences,Beijing,100850,China 2The Second Affiliated Hospital of Harbin Medical University,Harbin,150081,China |
| |
| Abstract: | Heme oxygenase-1(HO-1) is a key rate-limiting enzyme that catalyzes the degradation of heme and release biliverdin,carbon monoxide(CO) and iron(Fe2 ).It participates in maintaining cellular homeostasis and plays an important role in tissue protection by reducing oxidative injury,attenuating inflammatory response,inhibiting cell apoptosis,and increasing cell proliferation.Recent evidence indicates that HO-1 is often upregulated in tumor tissues,especially in solid tumor.On one hand,HO-1 facilitates tumor growth via its anti-apoptotic activity;on the other hand,it inhibits tumor proliferation.This review will discuss the relationship between HO-1 expression,HO-1 polymorphism,HO-1 anti-stress/apoptosis ability in solid tumor and formation/development of solid tumor. |
| |
| Keywords: | heme oxygenase-1(HO-1) solid tumor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
