MMP-9与COX-2蛋白在妊娠期高血压疾病患者母胎界面:底蜕膜中的表达及意义

目的 探讨MMP-9与COX-2蛋白在妊娠期高血压疾病患者母胎界面：底蜕膜中的表达、相互关系及其意义。方法 应用免疫组织化学法，选择妊娠期高血压疾病患者42例作为研究组，正常同期妊娠产妇40例作为对照组，分别检测底蜕膜中MMP-9、COX-2蛋白的表达情况。结果 1．42例妊娠期高血压疾病患者底蜕膜中MMP-9蛋白的阳性表达率为23.81％（10／42），40例正常同期妊娠产妇的阳性表达率为72.5％（29／40）。两组比较，妊娠期高血压疾病患者底蜕膜中MMP-9蛋白的阳性表达率显著低于正常同期妊娠产妇（P〈0．01）；2.42例妊娠期高血压疾病患者底蜕膜中COX-2蛋白的阳性表达率为64.29％（27／42），40例正常同期妊娠产妇COX-2蛋白的阳性表达率为15％（6／40）。两组比较，妊娠期高血压疾病患者底蜕膜中COX-2蛋白的表达阳性率显著高于正常同期妊娠产妇（P〈0 01）；3．两者在妊娠期高血压疾病患者底蜕膜中的表达存在显著负相关（r=-0.59，P〈0.01）。结论 妊娠期高血压疾病患者底蜕膜中MMP-9蛋白呈低表达、COX-2蛋白呈高表达，两者之间的表达呈负相关关系。MMP-2蛋白可能通过影响COX-2蛋白的表达导致妊娠期高血压疾病的发生发展。

The significance of MMP-9and COX-2 protein expression in the maternal -fetus interface: basal decidua of hypertensive disorder complicating pregnancy

Objective:To study the expression,the relationship and the significance of MMP-9 protein and COX-2 protein in the maternal-fetus interface:basal decidua.Methods:MMP-9 protein and COX-2 protein expression were examined by immunohistochemical method in 42 cases of hypertensive disorder complicating pregnancy and 40 cases of homeochronous normal pregnancy.Results:Decreased expression of MMP-9 protein was present in the basal decidua of hypertensive disorder complicating pregnancy.10 out of the 40 cases were MMP-9 protein positive(10/42,23.81%),which was significantly lower than that of normal pregnancy(29/40,72.5%)(P<0.01).Increased expression of COX-2 protein was present in the basal decidua of hypertensive disorder complicating pregnancy.27out of the 42 cases were COX-2 protein positive(27/42,64.29%),which was significantly higher than that of normal pregnancy(6/40,15%)(P<0.01).The expression of COX-2 protein was singnificantly inverse correlated with MMP-2 protein(r=-0.59,P<0.01).Conclusion:The higher expression of COX-2 protein and the lower expression of MMP-9 protein were found in the basal decidua of hypertensive disorder complicating pregnancy,existing inverse correlation.MMP-9 protein maybe influence the nidation of placenta by influence the expression of COX-2 protein,then influence the nosogenesis of hypertensive disorder complicating pregnancy.