Cerebral DARPP-32 expression after methylphenidate administration in young and adult rats |
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| Authors: | Renan P. Souza,Eliane C. Soares,Daniela V.F. Rosa,Bruno R. Souza,Karin M. Gomes,Samira S. Valvassori,Gislaine Z. Ré us,Cecí lia G. Iná cio,Má rcio R. Martins,Marcus V. Gomez,Joã o Quevedo,Marco A. Romano-Silva |
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| Affiliation: | 1. Laboratório de Neurociência, Departamento de Saúde Mental, Faculdade de Medicina da Universidade Federal de Minas Gerais, Av Alfredo Balena, 190, Belo Horizonte, 30130-100 – MG, Brazil;2. Laboratorio de Neurociências, Unidade Acadêmica de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil |
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| Abstract: | Dopamine may alter the phosphorylation state of DARPP-32 that plays a central role in the dopaminergic neurons biology. Studies have shown that DARPP-32/protein phosphatase 1 cascade is a major target for psychostimulants drugs. Methylphenidate is a psychostimulant that acts blocking the dopamine transporter has been used as an effective treatment for Attention Deficit Hyperactivity Disorder. We investigated if methylphenidate could alter DARPP-32 expression in five brain regions (striatum, hippocampus, prefrontal cortex, cortex and cerebellum) in young and adult rats. |
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| Keywords: | ADHD, Attention Deficit Hyperactivity Disorder MPH, methylphenidate DARPP-32, dopamine and cyclic adenosine 3&prime ,5&prime -monophosphate-regulated phosphoprotein Mr 32,000 |
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