Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina |
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| Authors: | Karen B. Larsen,Melissa Lutterodt,Martin F. Rath,Morten Mø ller |
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| Affiliation: | 1. Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark;2. Laboratory of Biology and Reproduction, Rigshospitalet, Denmark;3. Department of Gynecology and Obstetrics, Frederiksberg Hospital, Copenhagen, Denmark |
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| Abstract: | We studied the spatial and temporal expression of the homeobox genes PAX6, OTX2, and OTX1 using a developmental series of human fetal eyes aged from 6 to 10 weeks post-conception. Previous animal studies have shown that PAX6 may regulate progenitor cell proliferation, timing of differentiation and neural retina cell fate determination. OTX2 may play a role in development of the retinal pigment epithelium and photoreceptor differentiation, whereas OTX1 may be important in ciliary body development. |
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| Keywords: | Crx, cone-rod homeobox E, embryonic day kDa, kiloDalton mRNA, messenger RNA OTX1, orthodenticle homeobox 1 OTX2, orthodenticle homeobox 2 PAX6, paired box 6 PBS, phosphate buffered saline |
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