| 中西医结合治疗对萎缩性胃炎癌前病变环氧合酶-2蛋白表达及胃黏膜病理改变的影响 |
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| 引用本文： | 林一帆,宋福林,邹蕾,李昊燃,张续,陆宇平,杨卓,高文艳,巩阳,刘阳,陈山泉,王长洪.中西医结合治疗对萎缩性胃炎癌前病变环氧合酶-2蛋白表达及胃黏膜病理改变的影响[J].中国中西医结合消化杂志,2008,16(5):289-291. |
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| 作者姓名： | 林一帆 宋福林 邹蕾 李昊燃 张续 陆宇平 杨卓 高文艳 巩阳 刘阳 陈山泉 王长洪 |
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| 作者单位： | 沈阳军区总医院,中医科,国家中西医结合消化病重点专科,辽宁,沈阳,110015 |
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| 摘 要： | 目的]观察加味四君子汤联合甲硝唑、叶酸三联疗法对脾虚血瘀型萎缩性胃炎癌前病变患者环氧合酶-2（COX-2）蛋白表达的影响及胃黏膜病理改变。方法]68例脾虚血瘀型萎缩性胃炎和（或）伴有肠上皮化生（IM）及异型增生（Dys）患者均服用甲硝唑与叶酸,其中三联组34例同时服用加味四君子汤,甲硝唑服用1周,其他服用至第24周,用ABC免疫组化法检测COX-2蛋白。观察比较治疗前后COX-2蛋白表达及黏膜病理改变。结果]三联组治疗后COX-2蛋白表达较对照组减弱（P〈0.01）,病理改变逆转优于对照组（P〈0.05-0.01）。结论]脾虚血瘀与萎缩性胃炎癌前病变关系密切。中西医结合疗法能改善症状,一定程度逆转胃黏膜萎缩I、M和Dys,并降低COX-2蛋白表达。
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| 关 键 词： | 胃炎 萎缩性 癌前病变 中西医结合 环氧合酶-2 |
Expression of COX-2 in gastric mucosa in patients with atrophic gastritis and precancerous lesions treated by integrated TCM and western medicine |
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| LIN Yi-fan,SONG Fu-lin,ZHOU Lei,LI Hao-ran,ZHANG Xu,LU Yu-ping,YANG Zuo,GAO Wen-yan,GONG Yang,LIU Yang,CHEN Shan-quan,WANG Chang-hong.Expression of COX-2 in gastric mucosa in patients with atrophic gastritis and precancerous lesions treated by integrated TCM and western medicine[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2008,16(5):289-291. |
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| Authors: | LIN Yi-fan SONG Fu-lin ZHOU Lei LI Hao-ran ZHANG Xu LU Yu-ping YANG Zuo GAO Wen-yan GONG Yang LIU Yang CHEN Shan-quan WANG Chang-hong |
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| Institution: | LIN Yi-fan,SONG Fu-lin,ZHOU Lei,LI Hao-ran,ZHANG Xu,LU Yu-ping,YANG Zuo,GAO Wen-yan,GONG Yang,LIU Yang,CHEN Shan-quan,WANG Chang-hong(Department of Traditional Chinese Medicine , Gastroenterology,Hospital ofShenyang Military District,Shenyang 110015,China) |
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| Abstract: | Objective]To study the curative effects of symptom,mucosal changes,expression of COX-2 in chronic atrophic gastritis(CAG) and gastric precancerous lesion(GPL) differentiated as spleen deficiency and blood stasis by therapy of integrated TCM and western medicine.Methods]Sixty eight patients,diagnosed as CAG and GPL with gastroendoscopy and pathological examination,differentiated as spleen deficiency and blood stasis were randomly divided into treatment group(n=34),received Jiawei Sijunzi decoction + Metron... |
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| Keywords: | atrophic gastritis precancerous lesion therapy of integrated TCM and western medicine COX-2 |
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