Epilepsy and cerebellar ataxia associated with anti-glutamic acid decarboxylase antibodies |
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Authors: | Vulliemoz S Vanini G Truffert A Chizzolini C Seeck M |
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Institution: | Department of Neurology, University Hospital of Geneva, Geneva, Switzerland. |
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Abstract: | Anti-glutamic acid decarboxylase (GAD) antibodies are described in stiff-person syndrome and also in other neurological syndromes, including cerebellar ataxia and epilepsy. This paper reports the case of a patient who had chronic focal epilepsy, upbeat nystagmus and cerebellar ataxia, associated with a polyautoimmune response including anti-GAD antibodies. Both gait and nystagmus improved markedly after immunosuppressive treatment with corticosteroids and azathioprine. After the introduction of benzodiazepines, previously refractory seizures were completely controlled. Anti-GAD antibodies should be actively sought out in pharmacoresistant epilepsy, particularly if other neurological abnormalities are present. Combined treatment with immunosuppressants and gammahydroxybutyric acidergic agents may be highly effective. |
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