Secondary metabolites of Cinnamosma madagascariensis and their alpha-glucosidase inhibitory properties |
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Authors: | Harinantenaina Liva Matsunami Katsuyoshi Otsuka Hideaki Kawahata Masatoshi Yamaguchi Kentaro Asakawa Yoshinori |
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Affiliation: | Graduate School Biomedical Sciences, Department of Pharmacognosy, Hiroshima University, Japan. |
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Abstract: | Two new drimane-type sesquiterpenes, cinnamadin (1) and cinnamodial 11alpha,12beta-dimethyl acetal (2), together with pereniporin B (3), ugandensolide (4), polygodial (5), capsicodendrin, cinnamodial (6), sitosterol, stigmasterol, lignoceric acid, cinnamosmolide (7), D-mannitol, and delta-tocotrienol were isolated from Cinnamosma madagascariensis. The structures of the new compounds were determined by physical, chemical, and spectroscopic evidence. Compound 7 and D-mannitol were isolated in high yield (5% and 1.36%, respectively). Evaluation of the alpha-glucosidase inhibitory properties of the isolated metabolites demonstrated that compounds 1 and 4 show moderate effects, while cinnamodial (6) exhibited the most potent activity. The chemosystematics of Cinnamosma species are also discussed. |
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