| Immunohistochemical Analysis of Growth Factor Expression and Localization in Gastric Coronary Vein of Cirrhotic Patients |
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| 引用本文： | YANG Zhen, TIAN Lei, PENG Lin, QIU Fazu(Department of Surgery,Tongji Hospital,Tongji Medical University Wuhan 430030). Immunohistochemical Analysis of Growth Factor Expression and Localization in Gastric Coronary Vein of Cirrhotic Patients[J]. 华中科技大学学报(医学英德文版), 1996, 16(4): 229-233. DOI: 10.1007/BF02888113 |
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| 作者姓名： | YANG Zhen TIAN Lei PENG Lin QIU Fazu(Department of Surgery Tongji Hospital Tongji Medical University Wuhan 430030) |
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| 作者单位： | Department of Surgery，Tongji Hospital，Tongji Medical University Wuhan 430030 |
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| 摘 要： | ＩｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｃａｌＡｎａｌｙｓｉｓｏｆＧｒｏｗｔｈＦａｃｔｏｒＥｘｐｒｅｓｓｉｏｎａｎｄＬｏｃａｌｉｚａｔｉｏｎｉｎＧａｓｔｒｉｃＣｏｒｏｎａｒｙＶｅｉｎｏｆＣｉｒｒｈｏｔｉｃＰａｔｉｅｎｔｓ￥ＹＡＮＧＺｈｅｎ；ＴＩＡＮＬｅｉ；Ｐ...
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| 收稿时间： | 1996-05-13 |
Immunohistochemical analysis of growth factor expression and localization in gastric coronary vein of cirrhotic patients |
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| Yang Zhen,Tian Lei,Peng Lin,Qiu Fazu. Immunohistochemical analysis of growth factor expression and localization in gastric coronary vein of cirrhotic patients[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1996, 16(4): 229-233. DOI: 10.1007/BF02888113 |
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| Authors: | Yang Zhen Tian Lei Peng Lin Qiu Fazu |
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| Affiliation: | (1) Department of Surgery, Tongji Hospital, Tongji Medical University, 430030 Wuhan |
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| Abstract: | Summary This study was designed to investigate the expression and localization of PDGF, bFGF, EGF, and TGFα in gastric coronary vein of cirrhotic (n = 30) and non-cirrhotic patients (n = 10) using immunohistochemical technique. The strongly positive immunostaining rate were 93 %, 89 %, 70 % and 68 % respectively in cirrhotic patients. The immunostaining was negative in non-cirrhotic patients. The damage to endothelium, hypertrophy and hyperplasia of vascular smooth muscle cells and vascular remodeling were seen in gastric coronary vein of cirrhotic patients. These results suggested that gastric coronary vein could produce growth factor during cirrhosis, the growth factor can act on the vascular function and/or structure via autocrine-paracrine mechanism. This project is supported by the National Natural Science Foundation of China (No. 39470685) |
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| Keywords: | growth factor gastric coronary vein cirrhosis |
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