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| 大鼠马桑内酯癫痫点燃模型P-170的表达 | |
| 引用本文： | 李怀苏,周东,柴慧霞,田林郁. 大鼠马桑内酯癫痫点燃模型P-170的表达[J]. 现代预防医学, 2006, 33(9): 1549-1550 |
| 作者姓名： | 李怀苏 周东 柴慧霞 田林郁 |
| 作者单位： | 1. 成都第二人民医院神经内科,成都,610017 2. 四川大学华西医学中心附属第一医院神经内科 3. 四川大学基础医学院生理教研室 |
| 摘 要： | 目的：探索大鼠马桑内酯癫痫点燃模型脑部星形胶质细胞及毛细血管内皮细胞P-170的表达。方法：用发作级数评分观察马桑内酯点燃大鼠，免疫组化法测定P-170蛋白的表达。结果：点燃大鼠脑部广泛区域的P-170表达较未点燃大鼠和正常大鼠显著增强，P-170的表达与马桑内酯（CL）的剂量无相关性（P〉0．05）。结论：SD大鼠马桑内酯癫痫点燃模型可用于建立一种耐药性癫痫模型。 |
| 关 键 词： | 疾病模型 动物 马桑内酯 抗药性 |
| 文章编号： | 1003-8507（2006）09-1549-02 |
| 收稿时间： | 2005-11-21 |
| 修稿时间： | 2005-11-21 |
A NEW KINDLING MODEL INDUCED BY CDRIARIA LACIONE IN SD RATS AND THE EXPRESSION OF P - 170 |
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| LI Huai-su, ZHOU dong, CHAI Hui-xia,et al.. A NEW KINDLING MODEL INDUCED BY CDRIARIA LACIONE IN SD RATS AND THE EXPRESSION OF P - 170[J]. Modern Preventive Medicine, 2006, 33(9): 1549-1550 | |
| Authors: | LI Huai-su ZHOU dong CHAI Hui-xia et al. |
| Affiliation: | LI Huai-su, ZHOU dong, CHAI Hui-xia, et al. . |
| Abstract: | Objective:To detect the expression of P-170 in astrocytes and capillary endothelial in brains of SD rats kindled by Coriaria Lactone.Methods:The rats was observed by identifying the seizure stages and the expression of P-170 in the brains of all rats was tested by immunohistochemistry method.Result:Compared with unkindled rats and placebo rats,the expression of the P-170 staining in the brain samples of kindled rats were significantly increased.No dose relation has been observed in the staining area of P-170 in astrocytes of the brain samples from kindled rats(P>0.05).Conclusion Kindling SD rats induced by intramuscular injection of CL can be used as an animal models of intractable epilepsy. |
| Keywords: | Disease model, Animal Coriaria lactone Antiepileptic drug Drug resistance. |
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