实验性哮喘时神经生长因子对P物质的上调作用

目的：探讨实验性哮喘时神经生长因子（NGF）对P物质（SP）的调节机制。 方法： 应用放射免疫分析方法检测了NGF缺失时（鼻腔吸入NGF抗体）哮喘豚鼠下呼吸道和内脏感觉传入部位SP含量的变化。 结果： NGF缺失时哮喘豚鼠气管、支气管、肺、C7-T5段脊神经节及相应节段脊髓后角、结状神经节和孤束核区SP含量明显低于哮喘组和对照组（P<0.01）。 结论： 实验性哮喘时NGF可上调下呼吸道和感觉神经节等内脏感觉传入部位的P物质水平，两者共同参与支气管哮喘的发病过程。

Up-regulatory effect of nerve growth factor on substance P in the experimental asthma

AIM: To explore the regulatory mechanism of nerve growth factor (NGF) on substance P in the experimental asthmatic guinea pig. METHODS: Radioimmunoassay was used to determine the alteration of substance P levels in the lower respiratory tract and visceral sensory afferent sites while NGF was absent (inhalation of NGF antibody through nasal cavity) in the asthmatic guinea pig. RESULTS: The contents of substance P in the trachea, bronchus, lung, C7 - T5 spinal ganglia and the correspondent spinal dorsal horn, nodose ganglia and solitary nucleus area in the experimental asthmatic guinea pig with the absent of NGF in the respiratory tract, were much lower than those in the asthmatic and control groups (P < 0.01). CONCLUSION: NGF upregulates the contents of substance P in the lower respiratory tract and visceral sensory sites of the experimental asthmatic guinea pig, which might be involved in the pathogenesis of asthma.