| 大鼠妊娠期糖尿病影响胎鼠发育及仔鼠生长的研究 |
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| 引用本文： | 朱裕华,杜丹,朱孝荣. 大鼠妊娠期糖尿病影响胎鼠发育及仔鼠生长的研究[J]. 中国校医, 2010, 24(2): 94-96 |
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| 作者姓名： | 朱裕华 杜丹 朱孝荣 |
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| 作者单位： | 1. 徐州医学院实验动物中心,江苏,徐州,221002
2. 徐州医学院附属医院 |
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| 基金项目： | 徐州医学院科研基金(08KJ47) |
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| 摘 要： | 目的建立SD大鼠妊娠期糖尿病（GDM）模型，研究妊娠糖尿病对胎鼠发育及仔鼠生长的影响。方法40mg／kg链脲佐菌素（STZ）腹腔注射怀孕第1天大鼠复制GDM，5d后空腹检测血糖、尿糖和体质量。对照组注射等量柠檬酸钠缓冲液。孕鼠第13天、第19天剖宫产，观察其死胎、吸收胎、畸胎及存活胎数等，并测量胎鼠体质量。取4周龄仔鼠检测其血糖和体质量，并进行行为学观察。结果受孕第13天、第19天剖宫产，GDM组死胎、吸收胎、畸心胎数明显多于对照组；4周龄GDM组仔鼠体质量明显低于对照组，记忆力试验也低于对照组。8周龄GDM组仔鼠空腹血糖值显著高于对照组。结论大鼠妊娠糖尿病影响胎鼠正常发育，并导致仔鼠记忆力下降和血糖值升高。
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| 关 键 词： | 糖尿病 妊娠 妊娠合并糖尿病 大鼠 Sprague-Dawley 胎儿发育 |
Effect of gestational diabetes mellitus on fetal development and growth in rats |
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| ZHU Yu-hua,DU Dan,ZHU Xiao-rong. Effect of gestational diabetes mellitus on fetal development and growth in rats[J]. Chinese Journal of School Doctor, 2010, 24(2): 94-96 |
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| Authors: | ZHU Yu-hua DU Dan ZHU Xiao-rong |
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| Affiliation: | ZHU Yu-hua,DU Dan,ZHU Xiao-rong.Experimental Animal Center of Xuzhou Medical College,Xuzhou 221002,Jiangsu,China |
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| Abstract: | Objective To establish the SD rats' model of gestational diabetes mellitus(GDM) and study the effect of gestational diabetes mellitus on the fetal development and growth. Methods GDM was copied by intraperitoneal injection with 40 mg/kg streptozotocin(STZ) to the pregnant rats on the first day,and the blood glucose,urine glucose and body weight were measured 5 days later.The rats in the control group were injected with the same dose of sodium citrate buffer.The rats were anatomized to observe the stillbirth... |
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| Keywords: | Diabetes Gestational Pregnancy in Diabetics Rats Sprague Dawley Fetal Development |
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