| 关节软骨钙化层研究进展 |
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| 引用本文： | 宋伟,王富友,杨柳.关节软骨钙化层研究进展[J].中国修复重建外科杂志,2011(11):1339-1342. |
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| 作者姓名： | 宋伟 王富友 杨柳 |
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| 作者单位： | 第三军医大学西南医院关节外科中心; |
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| 基金项目： | 国家自然科学基金面上项目(30870639)~~ |
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| 摘 要： | 目的综述关节软骨钙化层的结构和功能及其在骨关节炎(osteoarthritis,OA)发病机制中的作用。方法广泛查阅近年来关于钙化层研究的文献,对钙化层的结构、成分、生物力学和生物化学功能进行总结分析。结果钙化层有特殊的结构和材料特性,并且具备半透膜的性质,钙化层软骨细胞保留部分生长板细胞特性,在维持正常软骨功能和OA发生、发展过程中起重要作用。因此重建关节软骨钙化层已成为近年来兴起的界面组织工程领域研究热点。结论对软骨钙化层的研究需要进一步深入,这在OA治疗和组织工程骨-软骨复合体制备方面都具有重要意义。
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| 关 键 词： | 钙化层 非钙化软骨 软骨下骨 骨关节炎 界面组织工程 |
RESEARCH PROGRESS OF CALCIFIED CARTILAGE ZONE |
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| SONG Wei,WANG Fuyou,YANG Liu.Center for Joint Surgery,Southwest Hospital,Third Military Medical University,Chongqing,P.R.China.RESEARCH PROGRESS OF CALCIFIED CARTILAGE ZONE[J].Chinese Journal of Reparative and Reconstructive Surgery,2011(11):1339-1342. |
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| Authors: | SONG Wei WANG Fuyou YANG LiuCenter for Joint Surgery Southwest Hospital Third Military Medical University Chongqing PRChina |
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| Institution: | SONG Wei,WANG Fuyou,YANG Liu.Center for Joint Surgery,Southwest Hospital,Third Military Medical University,Chongqing,400038,P.R.China |
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| Abstract: | Objective To review the structure and function of the calcified cartilage zone and its role in the pathogenesis of osteoarthritis(OA).Methods Recent literature about calcified zone was reviewed and analyzed in terms of architecture,composition,biomechanics,and biological function.Results Calcified zone has particular structure and material properties,and functions as a semipermeable membrane;chondrocytes in the calcified zone retain some characteristics of growth plate cells,which play a crucial role in car... |
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| Keywords: | Calcified zone Uncalcified cartilage zone Subchondral bone Osteoarthritis Interface tissue engineering |
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