| 高压氧对大鼠脑缺血再灌注损伤的保护作用及其对低氧诱导因子-1a的影响 |
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| 引用本文： | 王光胜,张克忠,王元伟,陈孝东.高压氧对大鼠脑缺血再灌注损伤的保护作用及其对低氧诱导因子-1a的影响[J].中风与神经疾病杂志,2010,27(4). |
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| 作者姓名： | 王光胜 张克忠 王元伟 陈孝东 |
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| 作者单位： | 1. 江苏省沭阳县人民医院神经内科,江苏沐阳,223600
2. 江苏省人民医院神经内科,江苏南京,210000 |
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| 摘 要： | 目的探讨高压氧(HBO)对脑缺血再灌注大鼠神经元的保护作用及其对低氧诱导因子(HIF)-1a的影响。方法选取SD大鼠30只,随机分为假手术组、模型组、治疗组,每组10只。采用线栓法建立脑缺血再灌注模型,采用TTC染色观察脑缺血再灌注大鼠梗死灶体积;行为学评分观察其神经功能缺损;蛋白印迹法观察HIF-1a的表达及HBO干预后的改变。结果与模型组相比,治疗组大鼠脑梗死灶体积,行为学评分及HIF-1a的表达均明显减少(P<0.05);与假手术组相比,治疗组HIF-1a的表达无明显增加(P>0.05)。结论HBO治疗能抑制组织HIF-1a的表达,从而对大鼠脑缺血再灌注损伤具有保护作用。
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| 关 键 词： | 高压氧 缺血再灌注 HIF-1a 大鼠 |
Effects of hyperbaric oxygen on neurologic impairment and expression of HIF-1a in brain of rats with cerebral ischemia-reperfusion |
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| WANG Guang-sheng,ZHANG Ke-zhong,WANG Yuan-wei,et al..Effects of hyperbaric oxygen on neurologic impairment and expression of HIF-1a in brain of rats with cerebral ischemia-reperfusion[J].Journal of Apoplexy and Nervous Diseases,2010,27(4). |
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| Authors: | WANG Guang-sheng ZHANG Ke-zhong WANG Yuan-wei |
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| Institution: | WANG Guang-sheng,ZHANG Ke-zhong,WANG Yuan-wei,et al.(Departments of Neurology,Shuyang People\'s Hospital,Shuyang 223600,China) |
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| Abstract: | Objective To investigate the effects of hyperbaric oxygen(HBO)on neurologic impairment and expression of hypoxia inducible factor-1a(HIF-1a)in brain of SD rats with cerebral ischemia-reperfusion.Methods 30 rats were randomly divided into 3 groups:sham-surgery group,model group and treatment group.Using method of pluging thread into middle cerebral artery,rat models of cerebral ischemia-reperfusion were made.The volume of infarction was observed by TTC staining,neurological impairment was valued by ethology ... |
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| Keywords: | Hyperbaric Oxygen Ischemia-reperfusion HIF-1a Rat |
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