阿托伐汀联用依那普利对老年单纯收缩期高血压的作用

目的 观察阿托伐汀联用依那普利对老年单纯收缩期高血压患者血压的影响.方法 老年单纯收缩期高血压78例,血清胆固醇正常.单用依那普利组38例,口服依那普利10 mg/d;联用阿托伐汀组40例,口服依那普利片10 mg/d和阿托伐汀20 mg/d.观察12周,每2周记录血压1次.结果 治疗12周后.两组患者收缩压、舒张压和脉压均较治疗前下降(P＜0.05);单用依那普利组脉压从治疗前(74±8)mm Hg降至(68±6)mm Hg;联用阿伐他汀组脉压从治疗前(75±7)mm Hg降至(60±6)mm Hg;两组间差异有统计学意义(t=5.255,P＜0.01).结论 阿托伐汀联用依那普利有助于改善单纯收缩期高血压老年人脉压,可降低老年心脑血管事件的危险性.

Effect of atorvastatin combined with enapril on isolated systolic hypertension in senile patients

Objectives To observe the effects of atorvastatin combined with enapril on pulse pressure (PP) in senile patients with isolated systolic hypertension(ISH). Methods Seventy-eight normocholesterolemic senile patients were divided into 2 groups. Enapril 10 mg/d was taken by 38 subjects in control group, 40 subjects in treatment group were administered with enapril 10 mg/d and atorvastatin 20 mg/d orally. Blood pressure was followed-up and recorded every two weeks for 12 week. Results The PP of senile patients ...