孕早期家用化学品使用与妊娠结局关系

目的 探讨孕早期家用化学品使用与3种不良妊娠结局（早产、低出生体重、小于胎龄儿）的关联情况。方法 选取在安徽省合肥、芜湖、马鞍山市妇幼保健部门进行孕产期保健体检并分娩单胎活产儿的10 269名育龄妇女为研究对象，分析不同特征育龄妇女孕早期家用化学品使用情况与不良妊娠结局关系。结果 美白霜的使用频率最高，其他家用化学品的使用频率较低，6 827人（66.5%）表示几乎不使用除美白霜以外的家用化学品；调查对象早产、低出生体重、小于胎龄儿发生率分别为3.4%、1.8%、3.2%；以几乎不用为对照组，二项logistic回归结果显示，家用化学品使用与低出生体重（RR=1.11，95%CI=0.83～1.49）、小于胎龄儿之间（RR=1.07，95%CI=0.85～1.33）无统计学关联，甚至在早产组呈现出一种保护效应（RR=0.73，95%CI=0.58～0.91）。结论育龄妇女孕早期家用化学品使用与3种不良妊娠结局不存在关联。

Association of household chemical use during first trimester pregnancy with risks of adverse birth outcomes

Objective To investigate effects of household chemical use during first trimester of pregnancy on adverse birth outcomes,including preterm birth(PB),low birth weight(LBW),and small for gestational age(SGA).Methods A total of 10 269 women of childbearing age who gave birth to single and live babies were recruited from October 2008 to October 2010 in 3 maternal and child health centers in Hefei,Wuhu,and Maanshan city.Chi-square test and binary logistic regression were used to analyze the association between household chemical use and adverse birth outcomes.Results Among the women,whitening cream was most frequently used during the first trimester,while the other household chemicals were rarely used.The incidence of PB,LBW,and SGA were 3.4%(343/10 120),1.8%(183/10 186),and 3.2%(324/10 091),respectively.The adjusted relative risks of PB,LBW,and SGA related to household chemical use were 0.73(95% confidence interval[95%CI]:0.58-0.91),1.11(95%CI:0.83-1.49),and 1.07(95%CI:0.85-1.33),respectively.Conclusion Overall,the results of the study did not suggest an association between household chemical use of pregnant women during the first trimester and adverse birth outcomes.