新疆维吾尔族居民hsCRP、IL-6与代谢综合征关系

目的 探讨维吾尔族人群高敏C反应蛋白（hsCRP）、白细胞介素6（IL-6）与代谢综合征（MS）及其组分的关系。方法 采用免疫比浊法、ELISA法、放射免疫法检测419名（MS组218例，对照组201人）研究对象的hsCRP、IL-6和空腹胰岛素（FINS），并测量身高、体重、血压、腰围（WC）、臀围（HC）及计算体质指数（BMI）和腰臀比（WHR）。结果 MS组hsCRP、IL-6水平均高于对照组（P<0.01）；随着MS组分个数的增多，hsCRP、IL-6水平均升高（P<0.01）；hsCRP的Q₄组与Q₁组相比，MS及其组分[高血压、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、高甘油三酯（TG）]检出率均增加（P<0.01，OR值分别为2.17、2.43、3.16、1.89）；IL-6的Q₄组与Q₁组相比，MS及其组分[高血压、低HDL-C、高TG、高胰岛素抵抗指数HOMA-IR）]检出率均增加（P<0.01，OR值分别为6.27、6.28、10.58、4.16、2.11）。结论 MS患者体内hsCRP、IL-6水平明显升高，hsCRP、IL-6与MS及其组分密切相关，hsCRP、IL-6水平升高是MS发生的重要标志。

Associations of metabolic syndrome with high-sensitive C-reactive protein and interleukin-6 among Uygur residents in Xinjiang

Objective To investigate associations of metabolic syndrome(MS)and its components with high-sensitive C-reactive protein(hsCRP)and interleukin-6(IL-6)among Uygur residents in Xinjiang Uygur Autonomous Region.Methods hsCRP,IL-6 and fasting insulin(FINS)of 419 residents were detected by using immune nephelometry,enzyme-linked immunosorbent assay(ELISA),and radio immunoassay and height,weight,blood pressure,waist circumference(WC),and hip circumference(HC)of the residents were measured;then the body mass index(BMI)and waist-to-hip ratio(WHR)were calculated.Results The concentrations of hsCRP and IL-6 were significantly higher in the residents with MS than those without MS.The level of hsCRP and IL-6 increased gradually along with the increment of the number of MS components(P<0.01).Detection rates of MS components,such as high blood pressure,hyperglycemia,and insulin resistance,were significantly higher in the residents with high level(quartile 4)of hsCRP and IL-6 when compared to those with lower level(quartile 1)(P<0.01).Conclusion The level of hsCRP and IL-6 are higher in Uygur residents with MS and rise along with the increment of the number of MS components.High concentration of serum hsCRP and IL-6 may be a valuable marker for MS.