蒙古族人群炎症标志物与平均动脉压及脉压关系

目的 探讨蒙古族人群炎症标志物C-反应蛋白（CRP）、细胞间黏附分子-1（ICAM-1）和E-选择素与平均动脉压（MAP）及脉压（PP）的关系。方法 整群抽取内蒙古自治区科左后旗和奈曼旗2个乡共2 589名年龄≥20岁的蒙古族居民进行问卷调查、体格检查和实验室检测包括CRP、ICAM-1、E-选择素及其他生化指标，按调查对象MAP及PP的第75百分位数为界分为MAP升高组（>108 mmHg）和正常组（≤108 mmHg），PP升高组（>50 mmHg）和正常组（≤50 mmHg），采用logistic回归分析炎症标志物与MAP和PP升高的关系。结果 MAP升高组的CRP和ICAM-1水平分别为（12.01±10.65）mg/L和（344.28±97.45）μg/L，均高于MAP正常组的（8.42±8.50）mg/L 和（323.73±97.55）μg/L，差异均有统计学意义（P<0.001）；PP升高组的CRP 和ICAM-1水平分别为（11.34±10.83）mg/L和（342.97±97.54）μg/L，均高于PP正常组的（8.66±8.54）mg/L和（324.39±97.63）μg/L，差异均有统计学意义（P<0.001）。多因素logistic回归分析结果表明，与CRP最低四分位者比较，最高四分位者MAP升高的OR（95%CI）为1.37（1.01~1.90）；与ICAM-1最低四分位者比较，最高四分位者PP升高的OR（95%CI）为1.38（1.03~1.85）。结论 在蒙古族人群中CRP水平与MAP呈正相关，ICAM-1水平与PP呈正相关。

Association of inflammatory biomarkers with mean arterial pressure and pulse pressure among Mongolians

Objective To investigate the relationship between inflammatory biomarkers,including C-reactive protein(CRP),intracellular adhesion molecule-1(ICAM-1)and E-selectin,with mean arterial pressure(MAP)and pulse pressure(PP)among Mongolians.Methods A total of 2 589 Mongolian residents aged 20 years and older were selected with cluster sampling from two adjacent townships located in Kezuohou Banner and Naiman Banner in Inner Mongolia and were required to complete a questionnaire survey,physical examination and laboratory detection including CRP,ICAM-1,E-selectin and other biochemical indicators.The panticipants were divided according 75 th percentile of MAP and PP into an elevated MAP group(>108 mmHg),normal MAP group(≤108 mmHg),elevated PP group(>50 mmHg),and normal PP group(≤50 mmHg).Logistic regression model was used to analyze the association between the inflammatory biomarkers and MAP and PP.Results The levels of CRP and ICAM-1(12.01±10.65 mg/L and 344.28±97.45μg/L)in the group with elevated MAP were higher than those in the group with normal MAP(8.42±8.50 mg/L and 323.73±97.55 μg/L)(all P<0.001).The levels of CRP and ICAM-1(11.34±10.83 mg/L and 342.97±97.54 μg/L)were higher in the group with elevated PP than those in the group with normal PP(8.66±8.54 mg/L and 324.39±97.63 μg/L)(all P<0.001).Multivariable logistic analysis showed that,compared with the lowest quartile of CRP,the multivariable adjusted odds ratio(OR)(95%confidence interral[95%CI])of elevated MAP for the highest quartile was 1.37(1.01-1.90),and compared with the lowest quartile of ICAM-1,the multivariable adjusted OR(95%CI)of elevated PP for the highest quartile was 1.38(1.03-1.85).Conclusion CRP is positively associated with MAP and ICAM-1 is positively associated with PP among Mongolians.