G蛋白偶联受体37与儿童孤独症关系

目的 探讨G蛋白偶联受体37与儿童孤独症的关系。方法 采用病例对照研究方法对120例孤独症患儿进行问卷调查及G蛋白偶联受体37（GPR37）含量测定。结果 病例组患儿血清GPR37表达水平为（12.27±1.73），对照组为（5.35±1.66），差异有统计学意义（t =31.61，P<0.001）。孤独症严重程度与血清GPR37表达水平均呈正相关（r=0.87，P<0.001）。结论 儿童孤独症的发病可能与血清中GPR37表达有关，GPR37的表达水平可能作为孤独症严重程度的指示因子。

Association between G protein-coupled receptors 37 and autism in children

Objective To evaluate the relationship between G protein-coupled receptors 37 and child autism.Methods From January 2013 to November 2013,120 child autism outpatients and 120 healthy children were recruited from a hospital in Shenyang city. Children autistic disorder was investigated based on a questionnaire survey and the level of G protein-coupled receptors 37 was detected using enzyme-linked immunosorbent assay.Results The level of G protein-coupled receptors 37 in childhood autism group(12.27±1.73)was significantly higher than that in healthy group(5.35±1.66,t=31.61,P<0.001). There was a positive correlation between G protein-coupled receptors 37 and childhood autism(r=0.87,P<0.001).Conclusion G protein-coupled receptors 37 may influence the development of children autistic disorder,and it may be an indicator for children autistic disorder.