| 肾母细胞瘤组织WT1、P53基因缺失检测 |
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| 引用本文： | 宋东奎,王瑞,步星耀,潘周辉. 肾母细胞瘤组织WT1、P53基因缺失检测[J]. 郑州大学学报(医学版), 2002, 37(3): 305-308 |
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| 作者姓名： | 宋东奎 王瑞 步星耀 潘周辉 |
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| 作者单位： | 1. 郑州大学第一附属医院泌尿外科,郑州,450052
2. 河南省人民医院外科,郑州,450003 |
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| 基金项目： | 河南省科技攻关项目资助课题9801187 |
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| 摘 要： | 目的：对肾母细胞瘤组织WT1、P53基因缺失情况进行检测。方法：30例 散发性肾母细胞瘤组织，其中上皮优势型6例，母细胞优势型14例，间质优势型10例，采用Southern印迹分子杂交技术检测肾母细胞瘤组织WT1、P53基因缺失，并分析其与组织类型的关系。结果：2例WT1基因的缺失为间质优势型肾母细胞瘤，1例P53等位基因缺失为间变型肾母细胞瘤。结论：WT1基因缺失可能与间质优势型肾母细胞瘤的发生有关，P53基因缺失可能与间变型肾母细胞瘤的发生有关。
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| 关 键 词： | 肾母细胞瘤 WT1基因 P53基因 基因缺失 |
| 修稿时间： | 2001-10-18 |
Deletion of WT1 and P53 genes in Wilms'' tumor tissues |
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| SONG Dongkui,WANG Rui,BU Xingyao,PAN Zhouhui. Deletion of WT1 and P53 genes in Wilms'' tumor tissues[J]. Journal of Zhengzhou University: Med Sci, 2002, 37(3): 305-308 |
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| Authors: | SONG Dongkui WANG Rui BU Xingyao PAN Zhouhui |
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| Affiliation: | SONG Dongkui,WANG Rui,BU Xingyao,PAN ZhouhuiDepartment of Urology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou450052 Department of Surgery,Henan Provincial People's Hospital,Zhengzhou 450003 |
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| Abstract: | Am:To study WT1 and P53 gene from 30 cases of sporadic Wilms' tumor. Methods: WT1 and P53 genes in 30 sporadic Wilms' tumor tissues (6 epithelium predominated Wilms' tumor, 14 metrocyte predominated Wilms', and 10 stroma predominated Wilms' tumor) were studied by southern bolt hybridization with WT1 cDNA and P53 cDNA probes. Results: Two cases with intragenic deletions of WT1 gene were histologically classified as stroma predominated Wilm's tumor. One case with allelic deletion of P53 was anaplastic Wilms' tumor. Conclusions: The deletion of WT1 gene may be correlated with stroma predominated Wilms' tumor and the P53 alteration may be correlated with the anaplasia of Wilms' tumor. |
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| Keywords: | Wilms' tumor WT1 gene P53 gene |
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