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The management of oral mucous membrane pemphigoid with dapsone and topical corticosteroid |
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| Authors: | Azizi Arash Lawaf Shirin |
| Affiliation: | Department of Oral Medicine, Faculty of Dentistry, Ahwaz University of Medical Sciences, Ahwaz, Iran;;Department of Prosthodontics, Faculty of Dentistry, Ahwaz University of Medical Sciences, Ahwaz, Iran |
| Abstract: | Statement of problem: Mucous membrane pemphigoid (MMP) is a chronic autoimmune subepithelial disease that primarily affects the mucous membranes of patients over the age of 50 years, resulting in mucosal ulceration and subsequent scarring. Purpose: The purpose of this study was to investigate the efficacy of dapsone in combination with topical corticosteroids to treat the oral lesions of MMP. Materials and methods: Twenty-two patients who had been diagnosed with MMP were selected. The oral features were graded according to severity of disease from 1 to 3. Each patient was assigned to one of four groups according to his or her response to therapy. Results: Five patients with mild to moderate disease were treated with topical corticosteroids alone for the duration of the study; 15 patients with moderate to severe disease were treated by topical corticosteroid with dapsone therapy. All of 15 patients had significant benefits. Conclusions: The use of dapsone in combination with topical corticosteroids is one of the most useful methods for the treatment of MMP. |
| Keywords: | corticosteroid dapsone mucous membrane pemphigoid pemphigus |