Rapid noninvasive optical imaging of tissue composition in breast tumor margins |
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| Authors: | Lee G. Wilke M.D. J. Quincy Brown Ph.D. Torre M. Bydlon B.S. Stephanie A. Kennedy B.S. Lisa M. Richards B.S. Marlee K. Junker M.S. Jennifer Gallagher B.S. William T. Barry Ph.D. Joseph Geradts M.D. Nimmi Ramanujam Ph.D. |
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| Affiliation: | aDepartment of Surgery, Duke University Health System, 3116 North Duke St., Durham NC 27704, USA;bDepartment of Biomedical Engineering, Duke University Medical Center, Durham, NC, USA;cDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA;dDepartment of Pathology, Duke University Medical Center, Durham, NC, USA |
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| Abstract: | BackgroundIn women undergoing breast conserving surgery (BCS), up to 60% can require re-excision. Our objective is to develop an optically based technology which can differentiate benign from malignant breast tissues intraoperatively through differences in tissue composition factors.MethodsA prospective study of optical imaging of BCS margins is being performed. Optical images are transformed into tissue composition maps with parameters of total hemoglobin concentration, b-carotene concentration and scattering. The predicted outcome is then compared to the margin-level pathology.ResultsFifty-five margins from 48 patients have undergone assessment. Within 34 specimens with pathologically confirmed positive margins, the ratio map of b-carotene/scattering showed the most significant difference reflecting a decrease in adipose and an increase in cell density within malignant margins (p=.002). These differences were notable in both in-situ and invasive disease.ConclusionsWe present a novel optical spectral imaging device that provides a rapid, non-destructive assay of the tissue composition of breast tumor margins. |
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| Keywords: | Breast conservation therapy Optical spectroscopy Imaging Margin assessment |
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