| 夫西地酸钠联合利福平对表皮葡萄球菌体外培养生物膜的作用 |
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| 引用本文： | 黄良库,徐涛,唐进,彭李华,陈世荣.夫西地酸钠联合利福平对表皮葡萄球菌体外培养生物膜的作用[J].中国组织工程研究与临床康复,2011,15(21):3891-3894. |
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| 作者姓名： | 黄良库 徐涛 唐进 彭李华 陈世荣 |
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| 作者单位： | 重庆医科大学第二医院,重庆市,400016 |
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| 摘 要： | 背景:表皮葡萄球菌是材料植入后感染的主要病原体,致病机制是在材料表面形成生物膜,生物膜形成后,单一用药抑制其细菌生长的效果较差。目的:建立表皮葡萄球菌生物膜体外模型,观察夫西地酸钠联合利福平对表皮葡萄球菌体外培养生物膜的作用。方法:体外培养生物膜,微量肉汤稀释法检测最低抑菌浓度,将低于最低抑菌浓度的夫西地酸钠和利福平单独或联合使用作用于表皮葡萄球菌早期与成熟期生物膜,观察其对表皮葡萄球菌早期和成熟生物膜的影响。结果与结论:夫西地酸钠和利福平均可抑制表皮葡萄球菌的黏附和生物膜的形成,对早期及成熟期生物膜内细菌有杀菌效应,二者联合应用后疗效明显优于单独应用(P<0.05)。提示夫西地酸钠联合利福平可明显抑制抑制表皮葡萄球菌的黏附和生物膜的形成,对早期及成熟期表皮葡萄球菌-生物膜有破坏作用,具有明显杀菌活性,是治疗细菌生物被膜相关感染的良好选择。
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| 关 键 词： | 生物膜 夫西地酸钠 利福平 表皮葡萄球菌 生物材料基础实验 |
Effects of fusidic sodium combining rifampicin on Staphylococcus epidermidis biofilm in vitro |
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| Huang Liang-ku,Xu Tao,Tang Jin,Peng Li-hua,Chen Shi-rong.Effects of fusidic sodium combining rifampicin on Staphylococcus epidermidis biofilm in vitro[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(21):3891-3894. |
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| Authors: | Huang Liang-ku Xu Tao Tang Jin Peng Li-hua Chen Shi-rong |
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| Institution: | Huang Liang-ku,Xu Tao,Tang Jin,Peng Li-hua,Chen Shi-rongThe Second Hospital of Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | BACKGROUND:Staphylococcus epidermidis is the major pathogen for the infection of the material after implantation,the underlying pathogenic mechanism is to form biofilm in the material surface,single drug administration is less effective to inhibit the growth of bacteria following biofilm formation.OBJECTIVE:To investigate the effect of fusidic sodium combining rifampicin on Staphylococcus epidermidis biofilm in vitro.METHODS:The biofilm was cultured in vitro.Tube dilution method was used to measure the mini... |
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