心肌肌钙蛋白T检测对维持性血透尿毒症患者心血管事件发生的临床意义

目的 探讨检测心肌肌钙蛋白T(cTnT)对维持性血透的尿毒症患者心血管事件发生的临床意义.方法 测定136例维持性血透尿毒症患者透析前、后的cTnT,每6个月测定cTnT 1次,随访3年,观察患者心血管事件及死亡事件发生情况,分析其与cTnT的关系.同时测定100名健康体检者的cTnT,并作对比分析.结果 维持性血透尿...

The clinical significance on the determination of cardiac troponin T for cardiovascular events in uremic patients undergoing hemodialysis

Objective To investigate the clinical significance on the determination of cardiac troponin T（cTnT） for cardiovascular events in uremic patients undergoing hemodialysis.Methods The cTnT was determined in 136 uremic patients undergoing maintaining hemodialysis before and after dialysis every 6 months.The cardiovascular events and death events were recorded during the follow-up period for 3 years,and the relationship with cTnT was analyzed.The cTnT of 100 healthy subjects were determined,and the results were comparatively analyzed.Results The differences of cTnT levels had statistical significance between in the uremic patients and in controls（P0.05）.The total mortality rate,cardiovascular mortality rate and occurrence of cardiovascular events in the cTnT increasing group were significant with those in the normal cTnT group（P0.05）.The cTnT was correlated with the mortality danger（r=0.52,P0.05）.The positive rate of cTnT in uremic patients was 30%.Conclusions In uremic patients undergoing hemodialysis,the cTnT is a risk factor for cardiovascular events and is related to the prognosis.The determination of cTnT is helpful for early diagnosis of cardiovascular events in uremic patients undergoing hemodialysis.