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| 多孔聚乙烯醇/明胶软骨组织工程支架复合材料的制备及其生物相容性 | |
| 引用本文： | 郭涛,韩志,杨天府,李玉宝,苑天红,肖杰,陈艺新. 多孔聚乙烯醇/明胶软骨组织工程支架复合材料的制备及其生物相容性[J]. 中国组织工程研究与临床康复, 2011, 15(25): 4587-4590. DOI: 10.3969/j.issn.1673-8225.2011.25.008 |
| 作者姓名： | 郭涛 韩志 杨天府 李玉宝 苑天红 肖杰 陈艺新 |
| 作者单位： | 1. 贵阳市第四人民医院骨科,贵州省贵阳市,550002 2. 贵阳中医学院,贵州省贵阳市,550002 3. 四川大学华西医院骨科,四川省成都市,610041 4. 四川大学分析测试中心,四川省成都市,610041 5. 贵阳医学院,贵州省贵阳市,550004 |
| 摘 要： | 背景:以明胶为基体制备的组织工程支架材料具有良好的生物相容性和生物降解性能,但存在力学性能低,降解速率难以控制的缺陷。目的:制备一种软骨组织工程支架材料多孔聚乙烯醇/明胶复合物,并检测其理化性能和生物相容性。方法:采用乳化发泡法制备聚乙烯醇/明胶多孔支架,并通过电镜分析、力学测试、皮下植入实验,检测材料孔径和孔隙率、IR光谱、力学性能和生物相容性。结果与结论:多孔材料内部呈三维网状多孔结构,孔径均匀,有相似的孔隙率61.8%,含水率44.6%,抗拉强度为(5.01±0.03)MPa,抗压强度为(1.47±0.36)MPa,有较好的力学性能,IR光谱分析表明材料内部结构均匀。皮下植入后,炎症反应逐渐减轻,囊壁逐渐变薄,并趋于稳定,提示多孔聚乙烯醇/明胶支架材料具有较好的生物相容性和力学性能。 |
| 关 键 词： | 多孔聚乙烯醇 明胶 软骨组织工程 支架 复合材料 |
Preparation and biocompatibility evaluation of composite scaffold material of polyvinyl alcohol/gelatin |
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| Guo Tao,Han Zhi,Yang Tian-fu,Li Yu-bao,Yuan Tian-hong,Xiao Jie,Chen Yi-xin. Preparation and biocompatibility evaluation of composite scaffold material of polyvinyl alcohol/gelatin[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(25): 4587-4590. DOI: 10.3969/j.issn.1673-8225.2011.25.008 | |
| Authors: | Guo Tao Han Zhi Yang Tian-fu Li Yu-bao Yuan Tian-hong Xiao Jie Chen Yi-xin |
| Affiliation: | Guo Tao1,Han Zhi2,Yang Tian-fu3,Li Yu-bao4,Yuan Tian-hong5,Xiao Jie1,Chen Yi-xin1 1Department of Orthopedics,Guiyang 4th People's Hospital,Guiyang 550002,Guizhou Province,China,2Guiyang College of Traditional Chinese Medicine,3Department of Orthopedics,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,4Centre of Analysis and Determination,5Guiyang Medical College,Guiyang 550004,Guizhou P... |
| Abstract: | BACKGROUND:The tissue engineered scaffolds prepared with gelatin as base have good biocompatibility and biodegradability,but low mechanical properties and difficulty to control degradation rate are their shortcomings.OBJECTIVE:To prepare a new type of composite scaffold material of polyvinyl alcohol/gelatin and to evaluate the biocompatibility of composite scaffold.METHODS:New type composite materials(polyvinyl alcohol/gelatin) were prepared by foaming method.The pore size and porosity,IR spectroscopy,mecha... |
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