| 注射聚丙烯酰胺水凝胶隆乳后的乳腺病变 |
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| 引用本文： | 孙艳花,宋建明,温文,关弘,许美权. 注射聚丙烯酰胺水凝胶隆乳后的乳腺病变[J]. 中国组织工程研究与临床康复, 2011, 15(25): 4623-4626. DOI: 10.3969/j.issn.1673-8225.2011.25.016 |
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| 作者姓名： | 孙艳花 宋建明 温文 关弘 许美权 |
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| 作者单位： | 深圳市第二人民医院病理科,广东省深圳市,518035 |
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| 摘 要： | 背景:聚丙烯酰胺水凝胶是一种人体软组织填充剂,主要用于注射隆乳,大量文献报道它会引起乳房硬结、感染、凝胶移位、乳房变形、乳腺增生甚至乳腺癌等并发症。目的:观察聚丙烯酰胺水凝胶注射隆乳后乳腺的病理学改变。方法:收集聚丙烯酰胺水凝胶注射隆乳后病例35例,采用苏木精-伊红染色、免疫组织化学染色、PAS和AB染色进行病理学观察。结果与结论:35例注射隆乳后的病例,26例发生了异物肉芽肿,发生率为74%(26/35);3例发生了乳腺癌,发生率为9%(3/35)。病灶内见大小不等的囊腔,部分囊腔完全由组织细胞、异物巨细胞和纤维组织填充。病变处和周围乳腺组织、脂肪及横纹肌组织均可见变性坏死,部分呈凝固性坏死。部分病例病变周围乳腺导管部分呈增生性改变,表现为普通型增生、不典型增生、原位癌或浸润癌,提示聚丙烯酰胺水凝胶对人体组织有毒性作用,会导致组织的变性坏死和引起异物肉芽肿反应,其和乳腺癌的发生有一定的相关性。
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| 关 键 词： | 聚丙烯酰胺水凝胶 隆乳 并发症 乳腺癌 异物肉芽肿 |
Breast lesions following breast augmentation with polyacrylamide hydrogel injection |
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| Sun Yan-hua,Song Jian-ming,Wen Wen,Guan Hong,Xu Mei-quan. Breast lesions following breast augmentation with polyacrylamide hydrogel injection[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(25): 4623-4626. DOI: 10.3969/j.issn.1673-8225.2011.25.016 |
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| Authors: | Sun Yan-hua Song Jian-ming Wen Wen Guan Hong Xu Mei-quan |
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| Affiliation: | Sun Yan-hua,Song Jian-ming,Wen Wen,Guan Hong,Xu Mei-quan Department of Pathology,the Second People's Hospital of Shenzhen City,Shenzhen 518035,Guangdong Province,China |
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| Abstract: | BACKGROUND:Polyacrylamide hydrogel is a kind of soft tissue fillers,mainly used for augmentation via injection.OBJECTIVE:To study the tissue pathology of breast lesions associated with polyacrylamide hydrogel injection for augmentation mammoplasty.METHODS:Thirty-five cases of breast lesions after polyacrylamide hydrogel injection were studied by using hematoxylin-eosin staining,immunohistochemical staining,PAS and AB staining.RESULTS AND CONCLUSION:Twenty-six cases showed foreign-body granuloma and 3 cases ... |
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