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| 可塑性纳米羟基磷灰石/聚羟基丁酸酯-羟基戊酸酯共聚物-聚乙二醇释药系统治疗兔骨髓炎 | |
| 引用本文： | 章柏平,汤善华,张立,吕仁发,卢海峰,靳安民,王旭东. 可塑性纳米羟基磷灰石/聚羟基丁酸酯-羟基戊酸酯共聚物-聚乙二醇释药系统治疗兔骨髓炎[J]. 中国组织工程研究与临床康复, 2011, 15(21): 3871-3876. DOI: 10.3969/j.issn.1673-8225.2011.21.017 |
| 作者姓名： | 章柏平 汤善华 张立 吕仁发 卢海峰 靳安民 王旭东 |
| 作者单位： | 1. 解放军第184医院骨科,江西省鹰潭市,335000 2. 南方医科大学珠江医院骨科,广东省广州市,510282 3. 华南理工大学生物工程与材料学院,广东省广州市,510200 |
| 摘 要： | 背景:现有的局部药物缓释系统多为块状,不能任意塑形,难以与骨腔完全贴敷,易导致骨髓炎复发,且药物爆释作用明显、载药量不大、释放时间短、有一定抗原性。为此,课题组与华南理工大学合作研制一种新型的可塑性局部药物缓释系统,以期为骨髓炎的治疗提供更好方法。目的:观察可塑性纳米羟基磷灰石/聚羟基丁酸酯-羟基戊酸酯共聚物-聚乙二醇[nanohydroxyapatite/poly(3-hydroxybutyrate-hydroxyvalerate)-polyethylene glycol,nano-HA/PHBV-PEG]载硫酸庆大霉素(gentamicin,GM)局部药物释放系统对骨髓炎的治疗作用。方法:制备兔胫骨近端骨髓炎模型,于胫骨近端骨窗内注入金黄色葡萄球菌后2周,行病灶清除。Ⅰ组植入1mL可塑性nano-HA/PHBV-PEG-GM局部药物释放系统;Ⅱ组植入可塑性nano-HA/PHBV-PEG1mL及23.2mg硫酸庆大霉素粉;Ⅲ组植入1mL可塑性nano-HA/PHBV-PEG并肌注硫酸庆大霉素5d,共23.2mg;Ⅳ组植入1mL可塑性nano-HA/PHBV-PEG;Ⅴ组无任何植入。术后8周进行放射学、组织学、细菌学检查。结果与结论:Ⅰ组细菌计数及改良X射线Norden骨髓炎评分极低,明显小于其他各组(P<0.01),其组织学观察无明显骨髓炎表现。Ⅱ、Ⅲ、Ⅳ组细菌计数逐渐增大,差异有显著性意义(P<0.01)。但3组间改良X射线Norden骨髓炎评分差异无显著性意义(P>0.05),组织学观察骨髓炎表现也无本质差别。Ⅱ、Ⅲ、Ⅳ组细菌计数及改良X射线Norden骨髓炎评分均较高,明显大于Ⅴ组(P<0.01或0.05);其组织学显示出严重骨髓炎表现。结果提示:①在病灶清除后,一期将可塑性nano-HA/PHBV-PEG-DDS植入残留的感染性骨缺损,能快速有效地治疗骨髓炎。②传统的全身抗生素应用或单纯局部应用抗生素方法虽然较不用抗生素好,但不能确保一期植骨有效治疗慢性骨髓炎。③在不用药、传统全身用药或单纯局部用药条件下,一期植骨反而会加重骨髓炎。 |
| 关 键 词： | 药物缓释系统 可塑性 纳米羟基磷灰石 骨髓炎 庆大霉素 |
Treatment of osteomyelitis in rabbits with plastic nanohydroxyapatite/poly (3-hydroxybutyrate-hydroxyvalerate)-polyethylene glycol drug delivery system |
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| Zhang Bo-ping,Tang Shan-hua,Zhang Li,Lu Ren-fa,Lü Hai-feng,Jin An-min,Wang Xu-dong. Treatment of osteomyelitis in rabbits with plastic nanohydroxyapatite/poly (3-hydroxybutyrate-hydroxyvalerate)-polyethylene glycol drug delivery system[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(21): 3871-3876. DOI: 10.3969/j.issn.1673-8225.2011.21.017 | |
| Authors: | Zhang Bo-ping Tang Shan-hua Zhang Li Lu Ren-fa Lü Hai-feng Jin An-min Wang Xu-dong |
| Affiliation: | Zhang Bo-ping1,Tang Shan-hua1,Zhang Li1,Lü Ren-fa1,Lu Hai-feng1,Jin An-min2,Wang Xu-dong31Department of Orthopaedics,No.184 Hospital of PLA,Yingtan335000,Jiangxi Province,China,2Department of Orthopaedics,Zhujiang Hospital,Southern Medical University,Guangzhou510282,Guangdong Province,3College of Biological Engineering and Materials Science,South China University of Technology,Guangzhou510200 |
| Abstract: | BACKGROUND:Existing local drug delivery system is mostly massive,cannot arbitrary moulding and is difficult to completely sticking with the bone cavity,which easily lead to recurrence of osteomyelitis,and obvious effect of drug burst release,small amount of drug loading,short releasing time,and certain antigenicity.Therefore,a new type of plastic local drug delivery system was developed by task force and South China University of Technology,in order to provide a better method of treatment of osteomyelitis.O... |
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