| 褪黑素对烫伤大鼠脑组织抗氧化能力与星形胶质细胞的影响 |
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| 引用本文： | 徐佳丽,张小林,龙天霖.褪黑素对烫伤大鼠脑组织抗氧化能力与星形胶质细胞的影响[J].中国实用医药,2011,6(20):5-7. |
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| 作者姓名： | 徐佳丽 张小林 龙天霖 |
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| 作者单位： | 贵州省毕节地区医院烧伤整形科,551700 |
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| 摘 要： | 目的 观察褪黑素(melatonin,MT)对烫伤大鼠脑组织GSH、SOD与MDA含量与星形胶质细胞的影响,以探讨烫伤后MT的神经保护机制.方法 随机将30只SD大鼠,分为正常对照组、烫伤组和MT治疗组;MT治疗组在烫伤后10 min,3 h分别给予MT (10 mg/kg)腹腔注射治疗,对照组与烫伤组给予等量体积的生理盐水.MT治疗结束后1 h取脑行GSH、SOD与MDA含量检测,然后取额叶皮质行GFAP免疫组化染色,光镜下观察星形胶质细胞的形态变化并进行计量分析.结果 与正常对照组相比,烫伤组大鼠脑组织GSH含量下降,而SOD与MDA含量增加,GFAP阳性神经元增多(P<0.05).与烫伤组相比,MT治疗组大鼠脑组织GSH含量增加,SOD与MDA含量下降,GFAP阳性神经元减少 (P<0.05).结论 烫伤后早期应用MT治疗,可以改善机体的氧化应激水平和神经系统的继发性损伤.
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| 关 键 词： | 褪黑素 烫伤 脑组织 氧化损伤 大鼠 |
Effect of Melatonin on oxidative stress and astrocyte in brain tissue of burns modal rats |
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| XU Jia-li,ZHANG Xiao-lin,LONG tian-lin.Effect of Melatonin on oxidative stress and astrocyte in brain tissue of burns modal rats[J].China Practical Medical,2011,6(20):5-7. |
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| Authors: | XU Jia-li ZHANG Xiao-lin LONG tian-lin |
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| Institution: | XU Jia-li,ZHANG Xiao-lin,LONG tian-lin.Department of Reshaping and Burns,Bijie Local Hospital of Guizhou Province,Guizhou 551700,China |
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| Abstract: | Objective To investigate the mechanism underlying the effects of Melatonin(MT)on burns vulnerated by steam,and study the changes of Glutathione,Malonaldehyde and Superoxide dismutase contents and astrocyte in rat cortex of frontal lobe.Methods The thirty mature Sprague-Dawley rats were randomly divided into the normal control group,the steam injury group and Melatonin treatment group.Melatonin(10 mg/kg.d)was injection into the abdominal cavity after 10 min and three hours in the Melatonin treatment group,an... |
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| Keywords: | Melatonin Burns Brain tissue Oxidative stress Rats |
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