| 沙利度胺联合FOLFIRI方案治疗晚期胃癌的临床观察 |
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| 引用本文： | 张敬伟,段冬梅,任中海.沙利度胺联合FOLFIRI方案治疗晚期胃癌的临床观察[J].中国实用医药,2011,6(20):40-41. |
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| 作者姓名： | 张敬伟 段冬梅 任中海 |
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| 作者单位： | 1. 河南省南阳市中心医院肿瘤科二区,473009
2. 河南省南阳医学高等专科学校 |
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| 摘 要： | 目的观察沙利度胺联合FOLFIRI方案治疗晚期胃癌的临床疗效和毒副反应。方法沙利度胺200 mg,睡前顿服,1～10 d;伊立替康150 mg/m2,静脉滴注90 min,第1天;甲酰四氢叶酸(CF)200 mg/m2,静脉滴注2 h,第1、2天,;5-氟尿嘧啶(5-FU),400 mg/m2,静脉推注,第1、2天,;5-FU 600mg/m2静脉滴注22 h,第1、2天。每2周重复,4周期后评定疗效。结果全组43例患者均可评价疗效,其中CR 4例(9.30%),PR 21例(48.84%),SD 13例(30.23%),PD 5例(11.63%),总有效率RR(CR+PR)58.14%,1年生存率71.88%。主要毒副作用为腹泻(9.38%)、白细胞降低(46.88%)、恶心呕吐(28.13%)。结论该方案治疗晚期结直肠癌有效率高,明显减轻了毒副作用。
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| 关 键 词： | 沙利度胺 晚期胃癌 伊立替康 化学治疗 |
Clinical study of FOLFIRI plus Thalidomide in the treatment of advanced gastric cancers |
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| ZHANG Jin-wei,DUAN Dong-mei,REN Zong-hai.Clinical study of FOLFIRI plus Thalidomide in the treatment of advanced gastric cancers[J].China Practical Medical,2011,6(20):40-41. |
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| Authors: | ZHANG Jin-wei DUAN Dong-mei REN Zong-hai |
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| Institution: | ZHANG Jin-wei,DUAN Dong-mei,REN Zong-hai,et al. Department of Oncology,Central Hospital of Nanyang,Nanyang,473009,China |
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| Abstract: | Objective To observe the therapeutic effects and adverse effect which consists of Thalidomide combined with FOLFIRI in treatment of advanced gastric cancers.Methods Thalidomide(200 mg/d,d1~10),chemotherapy of regimen irinotecan 150 mg/m2,90 minutes iv on day1,CF 200 mg/m2,2 hours iv on day 1 to 2,followed by 5-FU 400 mg/m2,iv and 600 mg/m2,22 hours on day 1 to 2,two weeks as one circle.Efficacy was evaluated after 4 circles.Results 43 patients with advanced intestinal cancers received,4 patients achieved co... |
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| Keywords: | Thalidomide Advanced intestinal cancers Irinotecan Chemotherapy |
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