| 甲基强的松龙对创伤性脑水肿中AQP4及MMP-9的影响 |
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| 引用本文： | 张宇,郝解贺,周鹏.甲基强的松龙对创伤性脑水肿中AQP4及MMP-9的影响[J].中国医疗前沿,2011(20):24-25,11. |
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| 作者姓名： | 张宇 郝解贺 周鹏 |
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| 作者单位： | 山西医科大学附属第一临床医院神经外科; |
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| 摘 要： | 目的研究大鼠创伤性脑水肿皮质中AQP-4与MMP-9的表达关系及甲强龙对其表达的影响。方法采用成年雄性SD大鼠随机分为甲强龙组（n=25）、模型组（n=25）、假手术组（n=5）;甲强龙组和模型组均采用改进Feeney法制作脑损伤模型。甲强龙组致伤后即刻腹腔内给药,模型组则注射对应生理盐水。根据处死时间分为6h、24h、3d、5d、7d,5组。过度麻醉并断头取脑,对损伤皮层采用HE染色及免疫组化进行AQP4与MMP-9的检测。结果在模型组与甲强龙组中6h已可见AQP4与MMP-9的表达,MMP-9与AQP-4的表达均在3d达到高峰,模型组AQP4及MMP-9的表达显著高于甲强龙组（P〈0.05）,相关系数（r=0.753,P〈0.01）。结论创伤性脑损伤后大鼠AQP4与MMP9的表达呈正相关;甲强龙冲击治疗能够通过下调AQP4及MMP9的表达来发挥减轻脑水肿的作用。
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| 关 键 词： | 大剂量甲强龙 创伤性脑损伤 水通道AQP-4 基质金属蛋白酶MMP-9 |
The influenced of expressions of MMP-9 and AQP-4 by High-dose Solu-Medrol in traumatic brain edema |
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| Abstract: | Objective To study the relationship between the expressions of MMP-9 and AQP-4 and to explore the mechanisms of influenced by Solu-Medrol in traumatic brain edema.Methods Fifty-five healthy adult male SD rats were randomly divided into sham operation group(n=5),model group(n=25) and the Solu-Medrol treatment group(n=25).The traumatic brain injury of the latter two groups were induced by Feeney's.Solu-Medrol treatment group underwent abdomen injection of Solu-Medrol after the injury.Model group underwent abd... |
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| Keywords: | High-dose Solu-Medrol Traumatic brain edema Aquaporin-4 Matrixmetalloproteinase-9 |
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