兰索拉唑四联疗法治疗幽门螺杆菌阳性胃溃疡临床观察

目的探讨兰索拉唑四联方案治疗幽门螺杆菌（Hp）阳性胃溃疡的临床疗效。方法采用随机数字表法将182例Hp感染的胃溃疡患者随机分为观察组和对照组，每组91例。观察组给予兰索拉唑＋阿莫西林克拉维酸钾＋克拉霉素＋果胶铋治疗。对照组给予奥美拉唑＋阿莫西林克拉维酸钾＋克拉霉素治疗。疗程为期7d。疗程结束4周后复查Hp，比较Hp根除率、症状缓解率及不良反应情况。结果以兰索拉唑为基础的四联疗法治疗Hp感染，其Hp根除率和临床总有效率均明显高于传统奥美拉唑为基础的三联疗法，两组相比差异具有统计学意义（P〈0．05）。治疗中患者不良反应较轻，仅少数患者出现头晕、恶心、腹泻症状，均可耐受，未影响治疗。结论以兰索拉唑为基础的四联方案治疗Hp感染阳性胃溃疡患者Hp根除率高，患者顺应性好，不良反应少，可在临床上推广应用。

The clinical observation of Lansoprazole-quadruple therapy for Helicobacter pylori-positive gastric ulcer

Objective To investigate the clinical efficacy of Lansoprazole-quadruple therapy for Helicobacter pylori-positive gastric ulcer.Methods 182 cases of Hp-positive gastric ulcer were randomly divided into two groups: the observation group and the control group.The patients in observation group were treated by Lansoprazole-quadruple therapy.The patients in control group were given omeprazole-Triple therapy for 7d.The Hp eradication rate,remission rate and adverse reactions were reviewed after 4 weeks.Results Th...