不同来源白花蛇舌草注射液过敏反应比较研究

目的研究白花蛇舌草注射液的致敏性并比较不同来源白花蛇舌草注射液过敏反应的差别,遴选优质药品。方法将实验动物分为阴性对照组、阳性对照组(卵清蛋白)、白花蛇舌草注射液组,通过豚鼠主动全身过敏反应(ASA)试验和大鼠皮肤被动过敏反应(PCA)试验对白花蛇舌草注射液的致敏性进行研究。结果 A厂家和C厂家ASA试验和PCA试验均为阴性,B厂家除两批样品PCA试验为阳性外,其余样品ASA试验和PCA试验为阴性。结论不同厂家生产的白花蛇舌草注射液由于生产条件不同等原因,其过敏反应存在差别,其鞣质的含量可能与PCA有关。

Comparison of allergic reactions of different Hedyotis diffusa Willd injection

Objective To study the allergic reactions of He@otis diffusa Willd injection, to compare the allergic reaction with respect to different He@otis diffusa Willd injections produced by different factories and to evaluate the qualities of them. Methods Experimental animals were divided into negative control group,positive control group（egg albumin） ,and He@otis diffusa WiUd injections groups. The allergic reactions caused by Hedyotis diffusa Willd injections were studied by active systemic anaphylaxis（ASA） test and passive cutane- ous anaphylaxis （PCA） test. Results ASA tests were negative and PCA tests were negative on samples from A and C factory. PCA tests were positive on two samples from B factory,the rest of samplesj tests were negative. Conclusions It showed the responses to Hedyotis diffusa Willd injections produced by different factories were different. The content of Tannin may be associated with adverse effects of Hedyotis d~＇usa WiUd injections in PCA test.