糖化血红蛋白(HbA1c)和冠脉病变复杂程度的相关性

目的探讨血清HbA1c水平和冠心病患者病变复杂程度的关系。方法对116例冠脉造影患者,根据病史分为单纯冠心病组(n=46)、冠心病合并糖尿病组(n=38)及对照组(n=32),并根据冠脉造影结果分为单支病变组(n=31)、双支病变组(n=27)和多支病变组(n=23)和对照组(n=35),根据冠脉造影行Gensini评分。比较HbA1c水平与冠脉病变的相关性。结果血清HbA1c水平病变组间有差异,随着冠脉程度增加,与Gensini积分呈显著正相关(r=0.314,p0.001)。结论 HbA1c水平与冠脉病变程度及危险因素有相关性,对冠心病患者的病变预测有较好的临床意义。

Relationship between glycosylated hemoglobin A_1c level and angiographical characteristics of coronary atherosclerosis

Objective To explore relationship between the level of serum glycosylated hemoglobin A~ c and the extent of cornoary lesions in coronary heart disease （CHD）. Methods The study concluded 116 consecutive patients and divided them into simple CHD gruop, CHD accompanied type 2 diabetes mellitus （T2DM） and control gruop（ n = 35 ）. And divided them into single-vessel lesin group（ n = 31 ）, double-vessel lesin group （ n = 27 ）, multi-vessel lesin group （ n = 23 ） and control gruop （ n = 35 ） according to the resuhs of angiogra- phy. Correlation between HbAl c levels and severity of coroary atherosclerosis has been analyzed based on the Gensini~ score of coronary atherosclerosis. Results There were significant differences between groups of serum HbA1 c levels. With the increment of coronary de- gree ,serum HbAle levels presented a strong positive-correlation with C, ensini scores（ r = 0. 314 ,p 〈 0. 001 ）. Conclusion The level of serum HbAj c was significantly associated with the severity of coronary atheroscleros. The investigation is useful for prediction of coronary lesions.