| 4-肼基苯磺酸特异性抑制SHP-2激活突变的乳腺癌细胞增殖 |
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| 引用本文： | 刘振邦,汪思应.4-肼基苯磺酸特异性抑制SHP-2激活突变的乳腺癌细胞增殖[J].安徽医药,2013,17(6):915-916. |
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| 作者姓名： | 刘振邦 汪思应 |
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| 作者单位： | 安徽医科大学基础医学院病理生理教研室,安徽,合肥,230032;安徽医科大学基础医学院病理生理教研室,安徽,合肥,230032 |
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| 基金项目： | 国家自然科学基金项目(项目编号：1072663) |
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| 摘 要： | 目的研究4-肼基苯磺酸对SHP-2激活突变的乳腺癌MDA-MB-231细胞株增殖的特异性抑制作用,为新型抗乳腺癌药物的开发提供些许参考。方法不同浓度的4-肼基苯磺酸处理SHP-2激活突变的MDA-MB-231细胞,用MTT法检测细胞的增殖。结果 4-肼基苯磺酸对乳腺癌MDA-MB-231细胞株的增殖有明显抑制作用,并呈剂量依赖性;同时对SHP-2低活性的对照组细胞无明显作用。结论 4-肼基苯磺酸可特异性地抑制SHP-2激活突变的乳腺癌MDA-MB-231细胞的体外增殖,这种抑制效果应是通过特异性抑制SHP-2异常增高的磷酸酶活性来实现的。
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| 关 键 词： | 4-肼基苯磺酸 乳腺癌 MDA-MB-231 SHP-2酪氨酸磷酸酶 |
Inhibition of 4-hydrazino benzenesulfonic acid on proliferation of breast cancer cells that SHP2 is mutated |
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| LIU Zhen-bang,WANG Si-ying.Inhibition of 4-hydrazino benzenesulfonic acid on proliferation of breast cancer cells that SHP2 is mutated[J].Anhui Medical and Pharmaceutical Journal,2013,17(6):915-916. |
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| Authors: | LIU Zhen-bang WANG Si-ying |
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| Institution: | 1 ( Pathophysiology Dapartment of Basic Medical College,Anhui Medical University,ttefei 230032, China ) |
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| Abstract: | Objective To provide a reference for developing novel anti-breast tumor drugs by study the effects of 4-hydrazino benzenesul- fonie acid on proliferation of breast cancer cells. Methods Proliferation of 4-hydrazino benzenesulfonic acid MDA-MB-231 cells that SHP2 is mutated treated by were measured by MMT assay. Results 4-hydrazino benzenesulfonic acid inhibited the proliferation of MDA- MB-231 cells in a dose-depended manner while the effects on CON cells are inconspicuous. Conclusion 4-hydrazino benzenesuffonic acid has anti-proliferation effects on MDA-MB-231 cells through inhibiting SHP2 than is mutated. |
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| Keywords: | 4-hydrazino benzenesulfonic acid breast cancer MDA-MB-231 SHP-2 tyrosine phosphatase |
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