儿童期单纯性肥胖的行为和内分泌变化及其相关性研究

为从神经心理和神经内分泌的角度探讨儿童期单纯性肥胖的发病机制，选择超过标准体重２０％的单纯肥胖症患儿６５例进行了Ａｃｈｅｎｂａｃｈ儿童行为量表（ＣＢＣＬ）测试和内分泌检测，并与５５例正常体重儿童比较。研究结果表明：①儿童期单纯性肥胖患者有行为缺陷，表现为社交能力低下（Ｐ＜０．０５）和行为问题困难（Ｐ＜０．００１）。②儿童期单纯性肥胖患者血浆胰岛素水平明显升高，生长激素和泌乳素水平明显降低。③儿童期单纯性肥胖患者的行为问题与内分泌代谢相关（ｒ＝０．４７７，Ｐ＜０．０５），其相关关系主要表现在社交情况与肾上腺素、泌乳素之间的相关。

Correlation between Behavior and Endocrine Changes in Children with Simple Obesity

The aim of present study is to investigate the mechanism of simple obesity in childhood from the neuropsychology and neuroendocrinology points of view. The child behavior checklist(CBCL)and plasma concentrations of several hormones were measured in 65 children with simple obesity, whose body weight was more than 20% heavier than standard weight. 55 healthy children were taken as normal control in the study. The results showed that obese children had behavior deficit manifested by lower ability of social communication(P<0.05)and difficulty of behavioral problem(P<0.001). Abnormality of endocrine metabolism was found in obese children, showing an increase of plasma level of insulin and a decrease of growth hormone and prolactin. Their behavioral deficit and endocrine changes were related to sex and the degree of obesity. The behavioral problem in obese children was correlated to their endocrine metabolism with r=0.477(P<0.05). The correlation mainly existed between social communication and epinephrine or prolactin. The results demonstrate that children with simple obesity have, to various extent, neuropsychological deficit and abnormal endocrine metabolism.