A technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography study in adolescent patients with major depressive disorder |
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Authors: | Ahmet Tutus Mustafa Kibar Seher Sofuoglu Mustafa Basturk Ali S Gönül |
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Institution: | Department of Nuclear medicine, Erciyes University School of Medicine, Kayseri, Turkey, TR Department of Nuclear Medicine, ?ukurova University School of Medicine, Kayseri, Turkey, TR Department of Psychiatry, Erciyes University School of Medicine, Kayseri, Turkey, TR
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Abstract: | We have not encountered any brain single-photon emission tomography (SPET) study performed in adolescent depressed patients
in the literature. Therefore, we used technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) brain SPET in adolescent patients with major depressive disorder (MDD) to examine the possible changes in cerebral
perfusion and the possible association between perfusion indices and clinical variables. Fourteen adolescent out-patients
(nine females, five males; mean±SD age: 13.11±1.43 years; range: 11–15 years) fulfilling the DSM-IV criteria for MDD and 11
age-matched healthy control subjects (six females, five males; mean±SD age: 13.80±1.60 years; range: 12–15 years) were included
in the study. 99Tc-HMPAO brain SPET was performed twice in the patient group and once in the control group. The first SPET investigation was
performed under non-medicated conditions and the second was performed after depressive symptoms had subsided. A relative perfusion
index (PI) was calculated as the ratio of regional cortical activity to the whole brain activity. We found significant differences
between the PI values of the untreated depressed patients and those of the controls, indicating relatively reduced perfusion
in the left anterofrontal and left temporal cortical areas. No significant differences in regional PI values were found between
the remitted depressed patients and the controls. Our study suggests that adolescent patients with MDD may have regional cerebral
blood flow deficits in frontal regions and a greater anterofrontal right-left perfusion asymmetry compared with normal subjects.
The fact that these abnormalities in perfusion indices have a trend toward normal values with symptomatic improvement suggests
that they may be state-dependent markers for adolescent MDD.
Received 11 January and in revised form 11 February 1998 |
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Keywords: | : Technetium-99m hexamethylpropylene amine oxime Brain single-photon emission tomography Adolescence Major depressive disorder |
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